Objective. To compare the safety and immunogenicity of 12 different acellular pertussis
vaccines combined with diphtheria and tetanus toxoids (DTaP) with one licensed diphtheria …

The number of pertussis cases in Japan has decreased dramatically following the
nationwide use of an acellular pertussis vaccine combined with diphtheria-tetanus toxoids …

In a double-blind, placebo-controlled efficacy trial of a monocomponent pertussis toxoid
vaccine, 3450 infants were randomly assigned to vaccination with diphtheria-tetanus toxoids …

In two double-blind, randomized, comparative studies involving a total of 218 children, an
acellular pertussis (DTPa) vaccine containing diphtheria and tetanus toxoids and pertussis …

Acellular pertussis vaccines combined with diphtheria and tetanus toxoids have proven to
be well tolerated, immunogenic and effective in reducing pertussis disease in adolescents …

Immunization against pertussis (whooping cough) has been part of the routine childhood
immunization program for over 50 years. Until 1997, a whole cell pertussis vaccine was …

BACKGROUND: Increasing incidence of pertussis in adolescents and adults has stimulated
the development of safe and immunogenic acellular pertussis vaccines for booster …

Background Pertussis has substantially increased in Quebec, Canada, since 1990. We
estimated pertussis vaccine effectiveness and vaccine coverage in child-care centers and …

Background In the United States, children receive five doses of diphtheria, tetanus, and
acellular pertussis (DTaP) vaccine before 7 years of age. The duration of protection after five …

Background Pertussis immunization of adults may be necessary to improve the control of a
rising burden of disease and infection. This trial of an acellular pertussis vaccine among …