The placenta is a complex fetal organ that fulfills pleiotropic roles during fetal growth. It
separates the maternal and fetal circulation, with which it is in contact through different …

The placenta plays a key role in sustaining fetal growth and development. Due to its position
between mother and fetus, it is exposed to changes in the intrauterine environment in both …

Women with normal glucose tolerance pre‐gravid and developing gestational diabetes in
late gestation have subclinical metabolic dysfunction prior to conception compared with …

Background: Gestational diabetes mellitus (GDM) is associated with increased fetal
adiposity, which may increase the risk of obesity in adulthood. The placenta has insulin …

In the 1980s, David Barker and Colleagues proposed that the major causes of
cardiovascular and metabolic diseases have their roots in early development. There is now …

Maternal diabetes constitutes an unfavorable environment for embryonic and fetoplacental
development. Despite current treatments, pregnant women with pregestational diabetes are …

Throughout its entire lifespan, the placenta is able to produce as well as respond to a variety
of inflammatory stimuli. Many signaling molecules and concurrent pathways responsible for …

A significant amount of information regarding the pathogenesis of gestational diabetes
mellitus (GDM) has been gathered since the Third Workshop-Conference on GDM. In spite …

By its location between maternal and fetal bloodstreams the human placenta not only
handles the materno-fetal transport of nutrients and gases, but may also be exposed to …

During embryogenesis in all mammalian species the placenta is formed inside the uterus by
apposition or fusion of maternally and embryonically-derived tissues. Genetically, normal …