Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease
DJ Selkoe, DS Bell, MB Podlisny, DL Price, LC Cork - Science, 1987 - science.org
The formation of clusters of altered axons and dendrites surrounding extracellular deposits
of amyloid filaments (neuritic plaques) is a major feature of the human brain in both aging …
of amyloid filaments (neuritic plaques) is a major feature of the human brain in both aging …
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
Amyloid deposition in senile plaques and the cerebral vasculature is a marker of Alzheimer's
disease. Whether amyloid itself contributes to the neurodegenerative process or is simply a …
disease. Whether amyloid itself contributes to the neurodegenerative process or is simply a …
Deposits of amyloid β protein in the central nervous system of transgenic mice
DO Wirak, R Bayney, TV Ramabhadran, RP Fracasso… - Science, 1991 - science.org
Alzheimer's disease is characterized by widespread deposition of amyloid in the central
nervous system. The 4-kilodalton amyloid β protein is derived from a larger amyloid …
nervous system. The 4-kilodalton amyloid β protein is derived from a larger amyloid …
Localization of amyloid β protein messenger RNA in brains from patients with Alzheimer's disease
The distribution of cells containing messenger RNA that encodes amyloid β protein was
determined in hippocampi and in various cortical regions from cynomolgus monkeys, normal …
determined in hippocampi and in various cortical regions from cynomolgus monkeys, normal …
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
D Goldgaber, MI Lerman, OW McBride, U Saffiotti… - Science, 1987 - science.org
Four clones were isolated from an adult human brain complementary DNA library with an
oligonucleotide probe corresponding to the first 20 amino acids of the β peptide of brain …
oligonucleotide probe corresponding to the first 20 amino acids of the β peptide of brain …
Brain to plasma amyloid-β efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease
The deposition of amyloid-β (Aβ) peptides into amyloid plaques precedes the cognitive
dysfunction of Alzheimer's disease (AD) by years. Biomarkers indicative of brain amyloid …
dysfunction of Alzheimer's disease (AD) by years. Biomarkers indicative of brain amyloid …
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
J Murrell, M Farlow, B Ghetti, MD Benson - Science, 1991 - science.org
Alzheimer's disease is a form of localized amyloidosis characterized by cerebral cortical
amyloid plaques, neurofibrillary tangles, and amyloid deposits within the walls of …
amyloid plaques, neurofibrillary tangles, and amyloid deposits within the walls of …
Amyloid β protein enhances the survival of hippocampal neurons in vitro
The β-amyloid protein is progressively deposited in Alzheimer's disease as vascular amyloid
and as the amyloid cores of neuritic plaques. Contrary to its metabolically inert appearance …
and as the amyloid cores of neuritic plaques. Contrary to its metabolically inert appearance …
Amyloid β protein precursor is possibly a heparan sulfate proteoglycan core protein
D Schubert, R Schroeder, M LaCorbiere, T Saitoh… - Science, 1988 - science.org
The amyloid β protein peptide is a major constituent of amyloid plaque cores in Alzheimer's
disease and is apparently derived from a higher molecular weight precursor. It is now shown …
disease and is apparently derived from a higher molecular weight precursor. It is now shown …
A century of Alzheimer's disease
M Goedert, MG Spillantini - science, 2006 - science.org
One hundred years ago a small group of psychiatrists described the abnormal protein
deposits in the brain that define the most common neurodegenerative diseases. Over the …
deposits in the brain that define the most common neurodegenerative diseases. Over the …