Molecular determinants underlying the production of siderophores in the human and animal
pathogen Staphylococcus aureus and the contribution of siderophore production to the …

Iron is critical for virtually all forms of life. The production of high‐affinity iron chelators,
siderophores, and the subsequent uptake of iron–siderophore complexes are a common …

Siderophores are key virulence factors that allow bacteria to grow in iron-restricted
environments. The Gram-positive pathogen Staphylococcus aureus is known to produce …

Despite the ability of staphylococci to grow in iron-restricted conditions in vivo, their iron
requirements and the mechanisms possessed by them for the uptake of iron are poorly …

Staphylococcus aureus possesses a multitude of mechanisms by which it can obtain iron
during growth under iron starvation conditions. It expresses an effective heme acquisition …

Siderophores are iron‐scavenging molecules produced by many microbes. In general, they
are synthesized using either non‐ribosomal peptide synthetase (NRPS) or NRPS …

Staphylococcus aureus is a versatile opportunistic human pathogen. Infection by this
bacterium requires uptake of iron from the human host, but iron is highly restricted in this …

S taphylococcus aureus elaborates two citrate‐containing siderophores, staphyloferrin A
(SA) and staphyloferrin B (SB), that enhance growth under iron‐restriction, yet …

The unique redox potential of iron makes it an ideal cofactor in diverse biochemical
reactions. Iron is therefore vital for the growth and proliferation of nearly all organisms …

Staphylococcus aureus is able to grow in the presence of extremely low iron concentrations
(0.04 µM). In iron-limiting conditions, this species develops alternative metabolic strategies …