Mechanical hyperalgesia is an early symptom of diabetic neuropathy. To evaluate the
mechanisms underlying this symptom, it was studied and compared in rat models of …

Hyperactivity of nociceptive C-fibers has been recently described in diabetic BB/Wistar rats.
This study assesses the association of hyperalgesia, using an analgesy-meter, with elevated …

In diabetes, chronic systemic hyperglycemia is associated with pain and other symptoms of
peripheral neuropathy. Evaluation of mechanisms causing these symptoms is complicated …

A modified von Frey filament test and an algesiometer paw pressure test were used to
measure mechanical nociceptive withdrawal thresholds of the hind limb of control rats and …

The triggers and pathogenesis of peripheral diabetic neuropathy are poorly understood, and
this study evaluated the role of insulinopenia in nociceptive abnormalities in the …

Painful neuropathy is common in human diabetes. In rats, experimental diabetes results in
altered pain sensitivity. We examined the effect of chronic insulin treatment on diabetes …

Decreased hind limb pressure pain threshold (PPT) is an early indicator of insulinopenia
and neuropathy developing in STZ-rat models of type 1 diabetes and pre-diabetes. To test if …

The effect exerted by different hyperglycemic states on the pain threshold and on the
analgesic potential of morphine was studied in male Sabra rats with the hot plate device …

Intensive diabetes treatment causes a considerable increase in the number of severe
hypoglycaemic episodes which could aggravate the progression of diabetic neuropathy …

Painful peripheral neuropathy is a common secondary complication of diabetes. The
streptozotocin (STZ)‐induced diabetic rat is the most commonly employed animal model …