Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight

M Oster, W Nuchchanart, N Trakooljul, E Murani… - European journal of …, 2016 - Springer
Purpose Maternal diet during pregnancy impacts foetal growth and development. In
particular, dietary levels of methylating micronutrients (methionine, folate, choline, vitamins …

A crucial role for maternal dietary methyl donor intake in epigenetic programming and fetal growth outcomes

M McGee, S Bainbridge, B Fontaine-Bisson - Nutrition reviews, 2018 - academic.oup.com
The fetal origins of health and disease framework has identified extremes in fetal growth and
birth weight as factors associated with the lifelong generation of chronic diseases such as …

Sex-specific muscular maturation responses following prenatal exposure to methylation-related micronutrients in pigs

M Oster, N Trakooljul, H Reyer, A Zeyner, E Muráni… - nutrients, 2017 - mdpi.com
Supplementation of micronutrients involved in DNA methylation, particularly during
pregnancy, is recommended because of its impacts on human health, but further evidence is …

[HTML][HTML] Methionine supply during late-gestation triggers offspring sex-specific divergent changes in metabolic and epigenetic signatures in bovine placenta

F Batistel, AS Alharthi, RRC Yambao, AA Elolimy… - The Journal of …, 2019 - Elsevier
Background Nonruminant male and female offspring respond differently to gestational
nutrition, with placenta contributing to the underlying mechanisms. However, similar data are …

Unique adaptations in neonatal hepatic transcriptome, nutrient signaling, and one-carbon metabolism in response to feeding ethyl cellulose rumen-protected …

V Palombo, A Alharthi, F Batistel, C Parys, J Guyader… - BMC genomics, 2021 - Springer
Abstract Background Methionine (Met) supply during late-pregnancy enhances fetal
development in utero and leads to greater rates of growth during the neonatal period. Due to …

Maternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspring

MV Cannon, DA Buchner, J Hester, H Miller… - PloS one, 2014 - journals.plos.org
Aims Epidemiological and animal studies have shown that maternal diet can influence
metabolism in adult offspring. However, the molecular mechanisms underlying these …

Maternal methyl-donor micronutrient supplementation during pregnancy promotes skeletal muscle differentiation and maturity in newborn and weaning pigs

Q He, T Zou, J Chen, L Jian, J He, Y Xia, F Xie… - Frontiers in …, 2020 - frontiersin.org
Adequate maternal methyl-donor micronutrient (MET) intake is an important determinant of
the organ development and metabolic renovation of offspring. The mechanism involved in …

Nutrigenetic and Epigenetic Mechanisms of Maternal Nutrition–Induced Glucolipid Metabolism Changes in the Offspring

P Jiao, H Lu, L Hao, AA Degen, J Cheng, Z Yin… - Nutrition …, 2024 - academic.oup.com
Maternal nutrition during pregnancy regulates the offspring's metabolic homeostasis,
including insulin sensitivity and the metabolism of glucose and lipids. The fetus undergoes a …

Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model

Y Lin, J Wu, Y Zhuo, B Feng, Z Fang, S Xu, J Li… - Journal of Animal …, 2024 - Springer
Background Intrauterine growth retardation (IUGR) affects intestinal growth, morphology,
and function, which leads to poor growth performance and high mortality. The present study …

Maternal methyl donors supplementation during lactation prevents the hyperhomocysteinemia induced by a high-fat-sucrose intake by dams

P Cordero, FI Milagro, J Campion… - International Journal of …, 2013 - mdpi.com
Maternal perinatal nutrition may program offspring metabolic features. Epigenetic regulation
is one of the candidate mechanisms that may be affected by maternal dietary methyl donors …