Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T …
HR Bohnenkamp, KT Papazisis, JM Burchell… - Cellular …, 2007 - Elsevier
Toll-like receptors (TLRs) recognise specific molecular signatures of pathogens and trigger
antimicrobial defence responses. Thereby, two independent signalling pathways can be …
antimicrobial defence responses. Thereby, two independent signalling pathways can be …
Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways
Inflammation is set off when innate immune cells detect infection or tissue injury. Tight
control of the severity, duration, and location of inflammation is an absolute requirement for …
control of the severity, duration, and location of inflammation is an absolute requirement for …
Toll-like receptor signaling and its inducible proteins
T Satoh, S Akira - Microbiology spectrum, 2016 - Am Soc Microbiol
Studies that bridge innate immunity and various diseases are making rapid advances.
Macrophages and dendritic cells play a leading role in innate immunity, using pattern …
Macrophages and dendritic cells play a leading role in innate immunity, using pattern …
Discovery and development of toll-like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases
CG Leon, R Tory, J Jia, O Sivak, KM Wasan - Pharmaceutical research, 2008 - Springer
Abstract Sepsis remains the most common cause of death in intensive care units in the USA,
with a current estimate of at least 750,000 cases per year, and 215,000 deaths annually …
with a current estimate of at least 750,000 cases per year, and 215,000 deaths annually …
Toll-like receptors and COVID-19: a two-faced story with an exciting ending
Coronavirus disease 19 (COVID-19) is caused by a novel single-stranded RNA beta-
coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[1] …
coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[1] …
Cytokine storm: the primary determinant for the pathophysiological evolution of COVID-19 deterioration
R Chen, Z Lan, J Ye, L Pang, Y Liu, W Wu… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global …
respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global …
Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists
S Federico, L Pozzetti, A Papa, G Carullo… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …
Toll-like receptors as a therapeutic target in the era of immunotherapies
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …
foreign and host molecules in order to initiate the immune response. They play a crucial role …
[HTML][HTML] Toll-like receptors in the pathogenesis of autoimmune diseases
AM Hosseini, J Majidi, B Baradaran… - Advanced …, 2015 - ncbi.nlm.nih.gov
Abstract Human Toll-like receptors (TLRs) are a family of transmembrane receptors, which
play a key role in both innate and adaptive immune responses. Beside of recognizing …
play a key role in both innate and adaptive immune responses. Beside of recognizing …
Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine?
Purpose Although the role of Toll-like receptors (TLRs) in bacterial infection and sepsis is
well characterized, recent studies have also shown that TLR4 and TLR2 can play an …
well characterized, recent studies have also shown that TLR4 and TLR2 can play an …