Toll-like receptors and innate immunity
Toll-like receptors (TLRs) are evolutionarily conserved innate receptors expressed in
various immune and non-immune cells of the mammalian host. TLRs play a crucial role in …
various immune and non-immune cells of the mammalian host. TLRs play a crucial role in …
Novel drugs targeting Toll-like receptors for antiviral therapy
MC Patel, KA Shirey, LM Pletneva… - Future …, 2014 - Taylor & Francis
Toll-like receptors (TLRs) are sentinel receptors of the host innate immune system that
recognize conserved'pathogen-associated molecular patterns' of invading microbes …
recognize conserved'pathogen-associated molecular patterns' of invading microbes …
[HTML][HTML] Negative regulation of Toll-like receptor signaling pathway
TLRs are primary sensors of invading pathogens, recognizing conserved microbial
molecules and activating signaling pathways that are pivotal to innate and adaptive immune …
molecules and activating signaling pathways that are pivotal to innate and adaptive immune …
Host innate immune responses to sepsis
WJ Wiersinga, SJ Leopold, DR Cranendonk… - Virulence, 2014 - Taylor & Francis
The immune response to sepsis can be seen as a pattern recognition receptor-mediated
dysregulation of the immune system following pathogen invasion in which a careful balance …
dysregulation of the immune system following pathogen invasion in which a careful balance …
Toll‐like receptor signaling pathways—therapeutic opportunities
J Zhu, C Mohan - Mediators of inflammation, 2010 - Wiley Online Library
Toll‐like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial
components. Triggering TLRs results in increased expression of multiple inflammatory …
components. Triggering TLRs results in increased expression of multiple inflammatory …
Cooperative molecular and cellular networks regulate Toll‐like receptor‐dependent inflammatory responses
GE Morris, LC Parker, JR Ward, EC Jones… - The FASEB …, 2006 - Wiley Online Library
Viral and bacterial pathogens cause inflammation via Toll‐like receptor (TLR) signaling. We
have shown that effective responses to LPS may depend on cooperative interactions …
have shown that effective responses to LPS may depend on cooperative interactions …
[HTML][HTML] Toll-like receptor signaling
Toll-Like Receptor Signaling Cold Spring Harbor Perspectives in Biology Skip to main page
content HOME ABOUT SUBJECT COLLECTIONS ARCHIVE SUBSCRIBE ADVERTISE …
content HOME ABOUT SUBJECT COLLECTIONS ARCHIVE SUBSCRIBE ADVERTISE …
Toll-like receptors: significance, ligands, signaling pathways, and functions in mammals
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling
immune functions with emphasis on their significance, function, regulation and expression …
immune functions with emphasis on their significance, function, regulation and expression …
The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …
[HTML][HTML] Toll-like receptor signaling pathways
T Kawasaki, T Kawai - Frontiers in immunology, 2014 - frontiersin.org
Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing
pathogen-associated molecular patterns derived from various microbes. TLRs signal …
pathogen-associated molecular patterns derived from various microbes. TLRs signal …