Toll-like receptors and innate immunity

H Kumar, T Kawai, S Akira - Biochemical and biophysical research …, 2009 - Elsevier
Toll-like receptors (TLRs) are evolutionarily conserved innate receptors expressed in
various immune and non-immune cells of the mammalian host. TLRs play a crucial role in …

Novel drugs targeting Toll-like receptors for antiviral therapy

MC Patel, KA Shirey, LM Pletneva… - Future …, 2014 - Taylor & Francis
Toll-like receptors (TLRs) are sentinel receptors of the host innate immune system that
recognize conserved'pathogen-associated molecular patterns' of invading microbes …

[HTML][HTML] Negative regulation of Toll-like receptor signaling pathway

J Wang, Y Hu, WW Deng, B Sun - Microbes and infection, 2009 - Elsevier
TLRs are primary sensors of invading pathogens, recognizing conserved microbial
molecules and activating signaling pathways that are pivotal to innate and adaptive immune …

Host innate immune responses to sepsis

WJ Wiersinga, SJ Leopold, DR Cranendonk… - Virulence, 2014 - Taylor & Francis
The immune response to sepsis can be seen as a pattern recognition receptor-mediated
dysregulation of the immune system following pathogen invasion in which a careful balance …

Toll‐like receptor signaling pathways—therapeutic opportunities

J Zhu, C Mohan - Mediators of inflammation, 2010 - Wiley Online Library
Toll‐like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial
components. Triggering TLRs results in increased expression of multiple inflammatory …

Cooperative molecular and cellular networks regulate Toll‐like receptor‐dependent inflammatory responses

GE Morris, LC Parker, JR Ward, EC Jones… - The FASEB …, 2006 - Wiley Online Library
Viral and bacterial pathogens cause inflammation via Toll‐like receptor (TLR) signaling. We
have shown that effective responses to LPS may depend on cooperative interactions …

[HTML][HTML] Toll-like receptor signaling

KH Lim, LM Staudt - Cold Spring Harbor perspectives in …, 2013 - cshperspectives.cshlp.org
Toll-Like Receptor Signaling Cold Spring Harbor Perspectives in Biology Skip to main page
content HOME ABOUT SUBJECT COLLECTIONS ARCHIVE SUBSCRIBE ADVERTISE …

Toll-like receptors: significance, ligands, signaling pathways, and functions in mammals

MK Vidya, VG Kumar, V Sejian, M Bagath… - International reviews …, 2018 - Taylor & Francis
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling
immune functions with emphasis on their significance, function, regulation and expression …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

[HTML][HTML] Toll-like receptor signaling pathways

T Kawasaki, T Kawai - Frontiers in immunology, 2014 - frontiersin.org
Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing
pathogen-associated molecular patterns derived from various microbes. TLRs signal …