Signal transduction by the Toll-like receptors (TLRs) is central to host defence against many
pathogenic microorganisms and also underlies a large burden of human disease. Thus, the …

Toll-like receptors (TLRs) play critical roles in host defense against microbes. In the past
decade, growing numbers of in vitro, in vivo and in silico studies have been performed and …

Hyperactivation of immune cells by bacterial products through toll-like receptors (TLRs) is
thought of as a causative mechanism of septic shock pathology. Infections with Gram …

Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory
diseases, and endogenous GCs play a key role in immune regulation. Toll-like receptors …

Sepsis and evolution of the innate immune response : Critical Care Medicine Sepsis and
evolution of the innate immune response : Critical Care Medicine SCCM Pediatric Critical Care …

Toll-like receptors (TLR) play a pivotal role in the innate immune response, and the
expression levels of these receptors may reflect the sensitivity of immune cells to infections …

Toll-like receptors (TLRs) play a crucial role in the recognition of invading pathogens and
the activation of subsequent immune responses against them. Individual TLRs recognize …

Toll-like receptors (TLRs) recognise highly conserved molecular structures, collectively
known as pathogen-associated molecular patterns. In the past two decades, development …

When microorganisms invade a host, the innate immune system first recognizes the
pathogen-associated molecular patterns of these microorganisms through pattern …

BACKGROUND Mammalian Toll-like receptor (TLR) proteins are pattern recognition
receptors for a diverse array of bacterial and viral products. Gram negative bacterial …