A landscape of the genetic and cellular heterogeneity in Alzheimer disease
Background Alzheimer disease (AD) has substantial genetic, molecular, and cellular
heterogeneity associated with its etiology. Much of our current understanding of the main AD …
heterogeneity associated with its etiology. Much of our current understanding of the main AD …
[HTML][HTML] Transcriptomic profiling of sporadic Alzheimer's disease patients
AB Caldwell, BG Anantharaman, S Ramachandran… - Molecular Brain, 2022 - Springer
Alzheimer's disease (AD) manifested before age 65 is commonly referred to as early-onset
AD (EOAD)(Reitz et al. Neurol Genet. 2020; 6: e512). While the majority (> 90%) of EOAD …
AD (EOAD)(Reitz et al. Neurol Genet. 2020; 6: e512). While the majority (> 90%) of EOAD …
[HTML][HTML] Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease
Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
A single cell brain atlas in human Alzheimer's disease
Alzheimer's disease (AD) is a heterogeneous disease that is largely dependent on the
complex cellular microenvironment in the brain. This complexity impedes our understanding …
complex cellular microenvironment in the brain. This complexity impedes our understanding …
A public resource of single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease
The emergence of technologies that can support high-throughput profiling of single cell
transcriptomes offers to revolutionize the study of brain tissue from persons with and without …
transcriptomes offers to revolutionize the study of brain tissue from persons with and without …
[HTML][HTML] Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
[HTML][HTML] Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease
E Miyoshi, S Morabito, CM Henningfield… - BioRxiv, 2023 - ncbi.nlm.nih.gov
The pathogenesis of Alzheimer's disease (AD) depends on environmental and heritable
factors, with remarkable differences evident between individuals at the molecular level. Here …
factors, with remarkable differences evident between individuals at the molecular level. Here …
[HTML][HTML] Single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease
The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the
study of Alzheimer's disease (AD). Integration with complementary multiomics data such as …
study of Alzheimer's disease (AD). Integration with complementary multiomics data such as …
[HTML][HTML] The complex genetic architecture of Alzheimer's disease: novel insights and future directions
SJ Andrews, AE Renton, B Fulton-Howard… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …
disorder and the most common form of dementia. AD is highly heritable, with heritability …
Multi-omic comparison of Alzheimer's variants in human ESC–derived microglia reveals convergence at APOE
Variations in many genes linked to sporadic Alzheimer's disease (AD) show abundant
expression in microglia, but relationships among these genes remain largely elusive. Here …
expression in microglia, but relationships among these genes remain largely elusive. Here …