p53 plays a critical role in tumor suppression. As a transcription factor, in response to stress
signals, p53 regulates its target genes and initiates stress responses, including cell cycle …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

As guardian of the genome the tumor suppressor p53 controls a crucial point in protection
from cellular damage and response to stressors. Activation of p53 can have beneficial (DNA …

Aging, like many other biological processes, is subject to regulation by genes that reside in
pathways that have been conserved during evolution. The insulin/IGF-1 pathway, mTOR …

The p53 tumor suppressor is a multifaceted transcription factor that responds to a diverse
array of stresses that include DNA damage and aberrant oncogene signaling. On activation …

In response to varying stress signals, the p53 tumor suppressor is able to promote repair,
survival, or elimination of damaged cells–processes that have great relevance to organismal …

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation
in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs …

Tp53 is a central regulator of cellular responses to stress and one of the most frequently
mutated genes in human cancers. P53 is activated by a myriad of stress signals and drives …

p53 is well known for suppressing tumors but could also affect other aging processes not
associated with tumor suppression. As a transcription factor, p53 responds to a variety of …

Mammalian aging is associated with elevated levels of oxidative damage of DNA, proteins,
and lipids as a result of unbalanced prooxidant and antioxidant activities. Accumulating …