Deep sequencing of patient genomes for disease diagnosis: when will it become routine?
SF Kingsmore, CJ Saunders - Science translational medicine, 2011 - science.org
Next-generation sequencing technologies have greatly lowered the cost of whole-genome
sequencing (WGS) and related approaches. Thus, comprehensive sequencing for …
sequencing (WGS) and related approaches. Thus, comprehensive sequencing for …
The Medical Genome Initiative: moving whole-genome sequencing for rare disease diagnosis to the clinic
Clinical whole-genome sequencing (WGS) offers clear diagnostic benefits for patients with
rare disease. However, there are barriers to its widespread adoption, including a lack of …
rare disease. However, there are barriers to its widespread adoption, including a lack of …
Sequencing set to alter clinical landscape
EC Hayden - Nature, 2012 - nature.com
Sequencing a patient's complete genome can cost as little as tests that target specific genes,
and in a handful of cases it has led to a life-changing diagnosis. No wonder the technology …
and in a handful of cases it has led to a life-changing diagnosis. No wonder the technology …
Whole-genome sequencing: a step closer to personalized medicine
B Pasche, D Absher - JAMA, 2011 - jamanetwork.com
THE PAST 60 YEARS HAVE WITNESSED REMARKABLE progress in genetics and
genomics from the descrip-tion of the DNA double helix by Watson and Crick1 to the release …
genomics from the descrip-tion of the DNA double helix by Watson and Crick1 to the release …
Clinical genome sequencing
The completion of the first draft of the Human Genome Project in 2001, and subsequent
refinements since then, have stimulated an explosion of research about the human genome …
refinements since then, have stimulated an explosion of research about the human genome …
Whole-genome sequencing: the new standard of care?
LR Brunham, MR Hayden - Science, 2012 - science.org
Rapid advances in DNA sequencing technology have made whole-genome sequencing
(WGS) both technically and economically feasible. WGS has been used with great effect in …
(WGS) both technically and economically feasible. WGS has been used with great effect in …
Next-generation sequencing in the clinic: are we ready?
LG Biesecker, W Burke, I Kohane, SE Plon… - Nature Reviews …, 2012 - nature.com
We are entering an era in which the cost of clinical whole-genome and targeted sequencing
tests is no longer prohibitive to their application. However, currently the infrastructure is not …
tests is no longer prohibitive to their application. However, currently the infrastructure is not …
Genomics in clinical practice: lessons from the front lines
HJ Jacob, K Abrams, DP Bick, K Brodie… - Science translational …, 2013 - science.org
The price of whole-genome and-exome sequencing has fallen to the point where these
methods can be applied to clinical medicine. Here, we outline the lessons we have learned …
methods can be applied to clinical medicine. Here, we outline the lessons we have learned …
implementing whole genome sequencing (WGS) in clinical practice: advantages, challenges, and future perspectives
The integration of whole genome sequencing (WGS) into all aspects of modern medicine
represents the next step in the evolution of healthcare. Using this technology, scientists and …
represents the next step in the evolution of healthcare. Using this technology, scientists and …
[HTML][HTML] Whole-genome sequencing breaks the cost barrier
L Bonetta - Cell, 2010 - cell.com
Whole-Genome Sequencing Breaks the Cost Barrier: Cell Skip to Main Content Advertisement
Cell This journal offers authors two options (open access or subscription) to publish research …
Cell This journal offers authors two options (open access or subscription) to publish research …