Autophagy has been recognized as a potential target for cancer therapy. The antimalarial
drug chloroquine (CQ) is able to inhibit autophagy and therefore is being considered for …

Chloroquine (CQ) is a 4-aminoquinoline drug used for the treatment of diverse diseases. It
inhibits lysosomal acidification and therefore prevents autophagy by blocking …

Autophagy is a conserved catabolic process that degrades cytoplasmic proteins and
organelles for recycling. The role of autophagy in tumorigenesis is controversial because …

Macroautophagy (herein referred to as autophagy) is a highly conserved mechanism for the
lysosomal degradation of cytoplasmic components. Autophagy is critical for the maintenance …

Recognition of the cytoprotective functions of autophagy that occur in tumor cells exposed to
various forms of chemotherapy or radiation has generated intense interest in the possibility …

Autophagy is a homeostatic cellular recycling system that is responsible for degrading
damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use …

Purpose Hydroxychloroquine (HCQ), the analog of chloroquine, augments the effect of
chemotherapies and radiotherapy on various tumors identified in the current clinical trials …

Autophagy is a complex of adaptive cellular response that enhances cancer cell survival in
the face of cellular stresses such as chemotherapy. Recently, chloroquine diphosphate …

Cellular stress induced by nutrient deprivation, hypoxia, and exposure to many
chemotherapeutic agents activates an evolutionarily conserved cell survival pathway termed …

Hydroxychloroquine (HCQ), the hydroxylated analog of chloroquine, is an antimalarial
lysomotropic agent that inhibits autophagy due to lysosomal acidification, and subsequently …