Foam cell formation plays an important role in the initiation and progression of
atherosclerosis. Aldehyde dehydrogenase 2 (ALDH2), a key enzyme for aldehyde …

Acetaldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme detoxifying
acetaldehyde and endogenous lipid aldehydes; previous studies suggest a protective role of …

Previous evidence has indicated a beneficial role for aldehyde dehydrogenase 2 (ALDH2)
in suppressing atherosclerotic plaque progression and instability. However, the underlying …

With the aim of identifying new target genes that could contribute to limit foam cell formation,
we analyzed changes in the pattern of gene expression in human THP-1 macrophages …

Inflammation in the vascular wall is important for development of atherosclerosis. We have
shown previously that arachidonate 15-lipoxygenase type B (ALOX15B) is more highly …

Objective—Aldose reductase (AR) is the rate-limiting enzyme of the polyol pathway. In
diabetes, it is related to microvascular complications. We discovered AR expression in foam …

Vascular smooth muscle cell (VSMC) foam cell formation is an important hallmark,
especially in advanced atherosclerosis lesions. Acyl-coenzyme A: cholesterol …

Background: Clinical studies show that the most common single-point mutation in humans,
ALDH2 (aldehyde dehydrogenase 2) rs671 mutation, is a risk factor for the development and …

Foam cells are a hallmark of atherosclerosis. However, it is unclear whether foam cell
formation per se protects against atherosclerosis or fuels it. In this study, we investigated the …

Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671
polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for …