Within the transient receptor potential (Trp) superfamily of ion channels, three members of
the Trp (melastatin)(TRPM) subfamily stand out as their amino acid sequences indicate that …

TRPM6 and TRPM7 are two known channel kinases that play important roles in various
physiological processes, including Mg2+ homeostasis. Mutations in TRPM6 cause …

TRPM7 is a polypeptide with intrinsic ion channel and protein kinase domains whose
targeted deletion causes cells to experience growth arrest within 24 hr and eventually die …

TRPM7 is a Ca2+-and Mg2+-permeable cation channel that also contains a protein kinase
domain. While there is general consensus that the channel is inhibited by free intracellular …

TRPM7 and its closest homologue, TRPM6, are the only known fusions of an ion channel
pore with a kinase domain. Deletion of TRPM7 in DT40 B-lymphocytes causes growth arrest …

TRPM6 and its homologue TRPM7 are α-kinase-coupled divalent cation-selective channels
activated upon reduction of cytosolic levels of Mg2+ and Mg· ATP. TRPM6 is vital for …

Abstract Zn2+, Mg2+ and Ca2+ are essential divalent cations implicated in many metabolic
processes and signalling pathways. An emerging new paradigm is that the organismal …

In the current review we will summarise data from the recent literature describing molecular
and functional properties of TRPM4. Together with TRPM5, these channels are up till now …

The channel kinases TRPM6 and TRPM7 are fusion proteins with an ion transport domain
and an enzymatically active kinase domain. TRPM7 has been found in every mammalian …

TRPM7 is a ubiquitously expressed nonspecific cation channel that has been implicated in
cellular Mg 2+ homeostasis. We have recently shown that moderate overexpression of …