Evidence for large-scale gene-by-smoking interaction effects on pulmonary function
Background: Smoking is the strongest environmental risk factor for reduced pulmonary
function. The genetic component of various pulmonary traits has also been demonstrated …
function. The genetic component of various pulmonary traits has also been demonstrated …
[HTML][HTML] A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
Interaction of cigarette smoking and polygenic risk score on reduced lung function
Importance The risk of airflow limitation and chronic obstructive pulmonary disease (COPD)
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …
[HTML][HTML] Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function
Genome-wide association studies have identified numerous genetic loci for spirometic
measures of pulmonary function, forced expiratory volume in one second (FEV1), and its …
measures of pulmonary function, forced expiratory volume in one second (FEV1), and its …
Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies
Background The identification of gene-by-environment interactions is important for
understanding the genetic basis of chronic obstructive pulmonary disease (COPD). Many …
understanding the genetic basis of chronic obstructive pulmonary disease (COPD). Many …
[HTML][HTML] Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function
Genome-wide association studies have identified numerous common genetic variants
associated with spirometric measures of pulmonary function, including forced expiratory …
associated with spirometric measures of pulmonary function, including forced expiratory …
Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin
Rationale Genome-wide association studies (GWASs) have identified numerous loci
associated with lower pulmonary function. Pulmonary function is strongly related to smoking …
associated with lower pulmonary function. Pulmonary function is strongly related to smoking …
Genome-wide gene-by-smoking interaction study of chronic obstructive pulmonary disease
W Kim, D Prokopenko, P Sakornsakolpat… - American journal of …, 2021 - academic.oup.com
Risk of chronic obstructive pulmonary disease (COPD) is determined by both cigarette
smoking and genetic susceptibility, but little is known about gene-by-smoking interactions …
smoking and genetic susceptibility, but little is known about gene-by-smoking interactions …
[HTML][HTML] Genome-wide assessment of gene-by-smoking interactions in COPD
B Park, SM Koo, J An, MG Lee, HY Kang, D Qiao… - Scientific reports, 2018 - nature.com
Cigarette smoke exposure is a major risk factor in chronic obstructive pulmonary disease
(COPD) and its interactions with genetic variants could affect lung function. However, few …
(COPD) and its interactions with genetic variants could affect lung function. However, few …
Genome‐wide association and network analysis of lung function in the Framingham Heart Study
Single nucleotide polymorphisms have been found to be associated with pulmonary function
using genome‐wide association studies. However, lung function is a complex trait that is …
using genome‐wide association studies. However, lung function is a complex trait that is …