The enormous regenerative capacity of the blood system to sustain functionally mature cells
are generated from highly proliferative, short‐lived progenitors, which in turn arise from a …

Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent
differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone …

Bone marrow, the site of hematopoiesis throughout adulthood, is a physiologically hypoxic
organ. Thus, various biological oxygen sensors and their signaling cascades play a pivotal …

ARTICLE SERIES: Stem Cells Cell Science at a Glance 3529 dormancy (Trumpp et al.,
2010) and, thereby, maintain homeostasis both in the steady state as well as in response to …

Significance: The effect of redox signaling on hematopoietic stem cell (HSC) function is not
clearly understood. Recent Advances: A growing body of evidence suggests that adult HSCs …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Highlights•The hematopoietic stem cell niche is a dynamic and complex environment.•
Summary of a webinar lead and moderated by experts of this topic.Hematopoietic stem cells …

Abstract Significance: Hematopoietic stem cells (HSCs) can sustain the production of blood
throughout one's lifetime. However, for proper self-renewal of its own population and …

Hematopoietic stem cells (HSCs) are uniquely capable of self-renewal and provision of all of
the mature elements of the blood and immune system throughout the lifetime of an …

The hematopoietic stem cell (HSC) niche is currently defined as the specific
microenvironment in the bone marrow (BM) which anatomically harbors HSCs and governs …