[HTML][HTML] Chlamydial plasmid-encoded virulence factor Pgp3 interacts with human cathelicidin peptide LL-37 to modulate immune response

S Hou, X Sun, X Dong, H Lin, L Tang, M Xue… - Microbes and …, 2019 - Elsevier
We have previously reported that Chlamydia trachomatis plasmid-encoded Pgp3 is able to
neutralize anti-chlamydial activity of human cathelicidin peptide LL-37 by binding to and …

Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37

S Hou, X Dong, Z Yang, Z Li, Q Liu… - Infection and …, 2015 - Am Soc Microbiol
Chlamydia trachomatis infection in the lower genital tract can ascend to and cause
pathologies in the upper genital tract, potentially leading to severe complications, such as …

Chlamydia trachomatis plasmid-encoding Pgp3 protein induces secretion of distinct inflammatory signatures from HeLa cervical epithelial cells

HC Cheong, YY Cheok, YT Chan, TF Tang… - BMC microbiology, 2023 - Springer
Abstract Background Genital Chlamydia trachomatis infection is the most common bacterial
sexual transmitted disease that causes severe complications including pelvic inflammatory …

Chlamydia trachomatis plasmid gene protein 3 is essential for the establishment of persistent infection and associated immunopathology

C Yang, L Kari, L Lei, JH Carlson, L Ma, CE Couch… - MBio, 2020 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding
trachoma and sexually transmitted disease afflicting hundreds of millions of people globally …

The Chlamydial Plasmid-Encoded Protein pgp3 Is Secreted into the Cytosol of Chlamydia-Infected Cells

Z Li, D Chen, Y Zhong, S Wang, G Zhong - Infection and immunity, 2008 - Am Soc Microbiol
The chlamydial cryptic plasmid encodes eight putative open reading frames (ORFs),
designated pORF1 to-8. Antibodies raised against these ORF proteins were used to localize …

Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL‐37

P Bergman, L Johansson, V Asp, L Plant… - Cellular …, 2005 - Wiley Online Library
Neisseria gonorrhoeae is a human pathogen causing the sexually transmitted disease
gonorrhoeae. The bacteria preferentially attach to and invade epithelial cells of the genital …

Plasmid-Encoded Pgp5 Is a Significant Contributor to Chlamydia muridarum Induction of Hydrosalpinx

Y Huang, Q Zhang, Z Yang, T Conrad, Y Liu, G Zhong - PloS one, 2015 - journals.plos.org
We have previously shown that the plasmid-encoded Pgp3 is a major virulence factor for C.
muridarum induction of hydrosalpinx. We now report that Pgp5 also plays a significant role …

The genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract

L Shao, T Zhang, J Melero, Y Huang, Y Liu… - Infection and …, 2018 - Am Soc Microbiol
The cryptic plasmid is essential for Chlamydia muridarum dissemination from the genital
tract to the gastrointestinal (GI) tract. Following intravaginal inoculation, a C. muridarum …

[HTML][HTML] Chlamydia-secreted protease CPAF degrades host antimicrobial peptides

L Tang, J Chen, Z Zhou, P Yu, Z Yang, G Zhong - Microbes and infection, 2015 - Elsevier
Chlamydia trachomatis infection in the lower genital tract, if untreated, can ascend to the
upper genital tract, potentially leading to complications such as tubal factor infertility. The …

Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice

Y Liu, Y Huang, Z Yang, Y Sun, S Gong… - Infection and …, 2014 - Am Soc Microbiol
Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been
used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic …