The liver has a remarkable capacity to regenerate after injury; yet, the role of macrophages
(MF) in this process remains controversial mainly due to difficulties in distinguishing …

Liver macrophages make up the largest proportion of tissue macrophages in the host and
consist of two dissimilar groups: Kupffer cells (KCs) and monocyte‑derived macrophages …

Although mechanisms of immune activation against liver ischemia reperfusion (IR) injury
(IRI) have been studied extensively, questions regarding liver-resident macrophages, that is …

Abstract Treatment of liver disease, caused by hepatotoxins, viral infections, alcohol
ingestion, or autoimmune conditions, remains challenging and costly. The liver has a …

Different etiologies such as drug toxicity, acute viral hepatitis B, or acetaminophen poisoning
can cause acute liver injury or even acute liver failure (ALF). Excessive cell death of …

Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of
hepatic macrophages even body tissue macrophages. They reside in liver sinusoids …

Background & Aims Kupffer cells (KCs), the resident tissue macrophages of the liver, play a
crucial role in the clearance of pathogens and other particulate materials that reach the …

Monocyte-derived macrophages (MoMF) play a pivotal role in the resolution of
acetaminophen-induced liver injury (AILI). Timely termination of neutrophil activity and their …

Macrophages are a heterogeneous population of innate immune cells and key cellular
components of the liver. Hepatic macrophages consist of embryologically-derived resident …

Noninfectious liver injury causes many acute and chronic liver diseases around the globe,
and particularly in developed nations. Bone marrow‐derived monocytes infiltrate the …