Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury
E Zigmond, S Samia-Grinberg… - The Journal of …, 2014 - journals.aai.org
The liver has a remarkable capacity to regenerate after injury; yet, the role of macrophages
(MF) in this process remains controversial mainly due to difficulties in distinguishing …
(MF) in this process remains controversial mainly due to difficulties in distinguishing …
[HTML][HTML] Role of macrophages in experimental liver injury and repair in mice
X Dong, J Liu, Y Xu, H Cao - Experimental and …, 2019 - spandidos-publications.com
Liver macrophages make up the largest proportion of tissue macrophages in the host and
consist of two dissimilar groups: Kupffer cells (KCs) and monocyte‑derived macrophages …
consist of two dissimilar groups: Kupffer cells (KCs) and monocyte‑derived macrophages …
Prolonged ischemia triggers necrotic depletion of tissue-resident macrophages to facilitate inflammatory immune activation in liver ischemia reperfusion injury
Although mechanisms of immune activation against liver ischemia reperfusion (IR) injury
(IRI) have been studied extensively, questions regarding liver-resident macrophages, that is …
(IRI) have been studied extensively, questions regarding liver-resident macrophages, that is …
Role of hepatic resident and infiltrating macrophages in liver repair after acute injury
Abstract Treatment of liver disease, caused by hepatotoxins, viral infections, alcohol
ingestion, or autoimmune conditions, remains challenging and costly. The liver has a …
ingestion, or autoimmune conditions, remains challenging and costly. The liver has a …
[HTML][HTML] Functional role of monocytes and macrophages for the inflammatory response in acute liver injury
HW Zimmermann, C Trautwein, F Tacke - Frontiers in physiology, 2012 - frontiersin.org
Different etiologies such as drug toxicity, acute viral hepatitis B, or acetaminophen poisoning
can cause acute liver injury or even acute liver failure (ALF). Excessive cell death of …
can cause acute liver injury or even acute liver failure (ALF). Excessive cell death of …
[HTML][HTML] Heterogeneity and function of kupffer cells in liver injury
W Li, N Chang, L Li - Frontiers in Immunology, 2022 - frontiersin.org
Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of
hepatic macrophages even body tissue macrophages. They reside in liver sinusoids …
hepatic macrophages even body tissue macrophages. They reside in liver sinusoids …
[HTML][HTML] Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions
L Beattie, A Sawtell, J Mann, TCM Frame, B Teal… - Journal of …, 2016 - Elsevier
Background & Aims Kupffer cells (KCs), the resident tissue macrophages of the liver, play a
crucial role in the clearance of pathogens and other particulate materials that reach the …
crucial role in the clearance of pathogens and other particulate materials that reach the …
[HTML][HTML] Ly6Chi Monocytes and Their Macrophage Descendants Regulate Neutrophil Function and Clearance in Acetaminophen-Induced Liver Injury
N Graubardt, M Vugman, O Mouhadeb… - Frontiers in …, 2017 - frontiersin.org
Monocyte-derived macrophages (MoMF) play a pivotal role in the resolution of
acetaminophen-induced liver injury (AILI). Timely termination of neutrophil activity and their …
acetaminophen-induced liver injury (AILI). Timely termination of neutrophil activity and their …
Macrophages as key regulators of liver health and disease
E Papachristoforou, P Ramachandran - International Review of Cell and …, 2022 - Elsevier
Macrophages are a heterogeneous population of innate immune cells and key cellular
components of the liver. Hepatic macrophages consist of embryologically-derived resident …
components of the liver. Hepatic macrophages consist of embryologically-derived resident …
Infiltrating monocytes in liver injury and repair
KJ Brempelis, IN Crispe - Clinical & translational immunology, 2016 - Wiley Online Library
Noninfectious liver injury causes many acute and chronic liver diseases around the globe,
and particularly in developed nations. Bone marrow‐derived monocytes infiltrate the …
and particularly in developed nations. Bone marrow‐derived monocytes infiltrate the …
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