Moment-to-moment changes in local neuronal activity lead to dynamic changes in cerebral
blood flow. Emerging evidence implicates astrocytes as one of the key players in …

Astrocytes send processes to synapses and blood vessels, communicate with other
astrocytes through gap junctions and by release of ATP, and thus are an integral component …

The tight spatial and temporal coupling between neuronal activity and blood flow ensures
that active brain regions receive an adequate supply of oxygen and energetic metabolites …

Neuronal activity results in increased blood flow in the brain, a response named functional
hyperemia. Astrocytes play an important role in mediating this response. Neurotransmitters …

In order to maintain normal brain function, it is critical that cerebral blood flow (CBF) is
matched to neuronal metabolic needs. Accordingly, blood flow is increased to areas where …

The brain is critically dependent on oxygen and glucose supply for normal function. Various
neurovascular control mechanisms assure that the blood supply of the brain is adequate to …

Astrocytes are the most numerous cells in the CNS. It is a defining feature of brain anatomy
that every astrocyte has at least one contact with the vasculature, termed an endfoot …

From a structural perspective, the predominant glial cell of the central nervous system, the
astrocyte, is positioned to regulate synaptic transmission and neurovascular coupling: the …

Astrocytes are the most common glial cells in the brain with fine processes and endfeet that
intimately contact both neuronal synapses and the cerebral vasculature. They play an …

Normal brain function requires proper supply of oxygen and glucose in a timely and local
manner. This is achieved through an orchestrated intercellular communication between …