Identification of Key Genes and Regulatory Pathways in Multiple Sclerosis Brain Samples: A Meta-Analysis of Micro-Array Datasets

MI Jansen, A Castorina - International Journal of Molecular Sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS)
whose aetiology is only partly understood. Investigating the intricate transcriptional changes …

Gene expression profiling in multiple sclerosis brain

R Dutta, BD Trapp - Neurobiology of disease, 2012 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system and the leading cause of non-traumatic neurological disability in young …

Identification of key target genes and biological pathways in multiple sclerosis brains using microarray data obtained from the Gene Expression Omnibus database

W Zheng, Y Chen, H Chen, W Xiao, YJ Liang… - Neurological …, 2018 - Taylor & Francis
Objective: The purpose of this study was to investigate critical genes in multiple sclerosis
(MS) using microarray data from brain tissue in MS. Materials: The expression profile data …

Transcriptomic meta-analysis of multiple sclerosis and its experimental models

BBR Raddatz, F Hansmann, I Spitzbarth, A Kalkuhl… - PloS one, 2014 - journals.plos.org
Background Multiple microarray analyses of multiple sclerosis (MS) and its experimental
models have been published in the last years. Objective Meta-analyses integrate the …

Investigation of differentially expressed genes and dysregulated pathways involved in multiple sclerosis

SU Kumar, A Datta, R Gnanasambandan… - Advances in protein …, 2022 - Elsevier
Multiple Sclerosis (MS) is a neurodegenerative autoimmune and organ-specific
demyelinating disorder, known to affect the central nervous system (CNS). While genetic …

Gene expression changes underlying cortical pathology: clues to understanding neurological disability in multiple sclerosis

R Dutta - Multiple Sclerosis Journal, 2013 - journals.sagepub.com
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system with an unknown etiology. The clinical disease course is variable, with the …

Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis

N Safari-Alighiarloo, M Rezaei-Tavirani, M Taghizadeh… - PeerJ, 2016 - peerj.com
Background The involvement of multiple genes and missing heritability, which are dominant
in complex diseases such as multiple sclerosis (MS), entail using network biology to better …

Genomics in multiple sclerosis—current state and future directions

M Comabella, R Martin - Journal of neuroimmunology, 2007 - Elsevier
Microarray-based gene expression profiling of large numbers of genes or even the whole
genome has only recently become possible. Several studies have employed this technology …

Microarray gene expression profiling analysis combined with bioinformatics in multiple sclerosis

M Liu, X Hou, P Zhang, Y Hao, Y Yang, X Wu… - Molecular biology …, 2013 - Springer
Multiple sclerosis (MS) is the most prevalent demyelinating disease and the principal cause
of neurological disability in young adults. Recent microarray gene expression profiling …

A comprehensive exploration of the transcriptomic landscape in multiple sclerosis: a systematic review

L Chiricosta, S Blando, S D'Angiolini… - International Journal of …, 2023 - mdpi.com
Multiple Sclerosis (MS) is, to date, an incurable disease of the nervous system characterized
by demyelination. Several genetic mutations are associated with the disease but they are …