The intensity of malaria transmission varies both naturally and as a consequence of human
public health intervention. The relationship between transmission intensity and the rate at …

The main factors affecting the evolution of drug resistance in malaria according to theoretical
models are reviewed here. The overwhelming influence on the emergence and rate of …

Does antimalarial drug resistance evolve faster in areas of high or low transmission?
Suggestions that resistance evolves faster in areas of low transmission cast a cloud over …

Plasmodium falciparum malaria is subject to artificial selection from antimalarial drugs that
select for drug-resistant parasites. We describe and apply a flexible new approach to …

Background The spread of drug resistance is making malaria control increasingly difficult.
Mathematical models for the transmission dynamics of drug sensitive and resistant strains …

In the late 1950's chloroquine resistance to Plasmodium falciparum occurred in South
America and on the Indochina Subcontinent. Since then it has conquered most of the areas …

Stochastic processes play a vital role in the early stages of the evolution of drug-resistant
malaria. We present a simple and flexible method for investigating these processes and …

Although the spread of drug resistance and the influence of climate change on malaria are
most often considered separately, these factors have the potential to interact through altered …

A succession of antimalarial drugs has been deployed to treat human falciparum malaria but
each has, in turn, been nullified by the spread of drug resistance. The consensus view has …

Background Most malaria-endemic countries are implementing a change in anti-malarial
drug policy to artemisinin-based combination therapy (ACT). The impact of different drug …