[HTML][HTML] SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation
J Feng, PF Yan, HY Zhao, FC Zhang… - Oncology …, 2016 - spandidos-publications.com
Abstract Sirtuin 6 (SIRT6) is a member of the mammalian NAD+‑dependent deacetylase
sirtuin family that acts to maintain genomic stability and to repress genes. SIRT6 has recently …
sirtuin family that acts to maintain genomic stability and to repress genes. SIRT6 has recently …
[HTML][HTML] Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway
P Mu, KUN Liu, Q Lin, W Yang, DAN Liu… - Oncology …, 2019 - spandidos-publications.com
Abstract Sirtuin7 (Sirt7) is a member of the Sir2 histone deacetylase family that functions in a
number of physiological processes, including cellular metabolism, ageing and apoptosis …
number of physiological processes, including cellular metabolism, ageing and apoptosis …
[HTML][HTML] Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal‑regulated kinase signaling pathway
ZG Zhang, CY Qin - Molecular medicine reports, 2014 - spandidos-publications.com
Sirt6, a member of the mammalian sirtuin family, is a protein that is located in the nucleus
and is an NAD+‑dependent deacetylase important in the control of metabolic activity and …
and is an NAD+‑dependent deacetylase important in the control of metabolic activity and …
Sirt2 suppresses glioma cell growth through targeting NF-κB–miR-21 axis
Y Li, D Dai, Q Lu, M Fei, M Li, X Wu - Biochemical and biophysical research …, 2013 - Elsevier
Sirtuins are NAD+-dependent deacetylases that regulate numerous cellular processes
including aging, DNA repair, cell cycle, metabolism, and survival under stress conditions …
including aging, DNA repair, cell cycle, metabolism, and survival under stress conditions …
[HTML][HTML] Overexpression of SIRT4 inhibits the proliferation of gastric cancer cells through cell cycle arrest
Y Hu, J Lin, Y Lin, X Chen, G Zhu… - Oncology …, 2019 - spandidos-publications.com
The sirtuins (SIRTs) are a family of nicotinamide-adenine dinucleotide (NAD)+‑dependent
protein deacetylases. SIRT4 is a mitochondrial NAD+‑dependent adenosine diphsophate …
protein deacetylases. SIRT4 is a mitochondrial NAD+‑dependent adenosine diphsophate …
[HTML][HTML] Sirt3 is a tumor suppressor in lung adenocarcinoma cells
K Xiao, J Jiang, W Wang, S Cao, L Zhu… - Oncology …, 2013 - spandidos-publications.com
Sirt3, a member of the mammalian sirtuin family protein that is localized to mitochondria, is a
NAD+-dependent deacetylase and plays an important role in the control of metabolic …
NAD+-dependent deacetylase and plays an important role in the control of metabolic …
SIRT2 activity is required for the survival of C6 glioma cells
X He, H Nie, Y Hong, C Sheng, W Xia… - … and biophysical research …, 2012 - Elsevier
SIRT2 is a tubulin deacetylase, which can play either detrimental or beneficial roles in cell
survival under different conditions. While it has been suggested that reduced SIRT2 …
survival under different conditions. While it has been suggested that reduced SIRT2 …
[HTML][HTML] The clinical significance of SIRT2 in malignancies: a tumor suppressor or an oncogene?
L Zhang, S Kim, X Ren - Frontiers in Oncology, 2020 - frontiersin.org
Sirtuin 2 (SIRT2) is a member of the sirtuin protein family. It is a Class III histone deacetylase
(HDACs) and predominantly localized to the cytosol. SIRT2 deacetylates histones and a …
(HDACs) and predominantly localized to the cytosol. SIRT2 deacetylates histones and a …
Trending topics of SIRT1 in tumorigenicity
LM Garcia-Peterson, X Li - Biochimica et Biophysica Acta (BBA)-General …, 2021 - Elsevier
Background Carcinogenesis is governed by a series of genetic alterations and epigenetic
changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1 (SIRT1), an NAD+ …
changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1 (SIRT1), an NAD+ …
The role of SIRT2 in cancer: A novel therapeutic target
G Chen, P Huang, C Hu - International Journal of Cancer, 2020 - Wiley Online Library
Abstract Sirtuin 2 (SIRT2) belongs to the sirtuins family. It exists in many tissues and organs
of the human body and regulates a wide range of biological functions. Studies have found …
of the human body and regulates a wide range of biological functions. Studies have found …