In the past decade, great interest has been shown in the role of sirtuin 1 (SIRT1) in
tumorigenesis. The published data show SIRT1 can function as both a tumor promoter and …

SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl
transferase and NAD+-dependent deacylase of both acetyl groups and long-chain fatty acyl …

Abstract Sirtuin-1 (SIRT1), the mammalian ortholog of yeast Sir2p, is well known to be a
highly conserved NAD+-dependent protein deacetylase that has been emerging as a key …

SIRT6, is a member of the NAD‑dependent sirtuin family of enzymes, and has been reported
as a novel tumor suppressor gene or oncogene, dependent on the type of cancer. However …

Abstract Sirtuin 1 (SIRT1), a member of the sirtuin protein family, is a nicotinamide adenine
dinucleotide (NAD+)‑dependent type III histone deacetylase and mono‑ADP …

Melanoma is an aggressive skin cancer that can rapidly metastasize to become fatal, if not
diagnosed early. Despite recent therapeutic advances, management of melanoma remains …

Decreased expression of the tumor suppressor sirtuin 6 (SIRT6) protein plays a role in
tumorigenesis. The aim of this study was to investigate the effects of SIRT6 and its …

Abstract Sirtuin 5 (SIRT5) is a member of the NAD+‑dependent class III protein
deacetylases. Although it is known that SIRT5 deacetylates and activates urate oxidase in …

Sirtuins are NAD+ dependent deacetylases and/or ADP-ribosyl transferases active on
histone and non-histone substrates. The first sirtuin was discovered as a transcriptional …

Purpose: To characterize the functional role of SIRT6 in hepatocellular carcinoma (HCC).
Experimental Design: The expression of SIRT6 in 60 paired paraffin-embedded HCC tissues …