Proteomics in biomarker discovery and drug development

QY He, JF Chiu - Journal of cellular biochemistry, 2003 - Wiley Online Library
Proteomics is a research field aiming to characterize molecular and cellular dynamics in
protein expression and function on a global level. The introduction of proteomics has been …

[HTML][HTML] Clinical proteomics: current status, challenges, and future perspectives

SH Chiou, CY Wu - The Kaohsiung journal of medical sciences, 2011 - Elsevier
This account will give an overview and evaluation of the current advances in mass
spectrometry (MS)-based proteomics platforms and technology. A general review of some …

[HTML][HTML] Revival of 2DE-LC/MS in proteomics and its potential for large-scale study of human proteoforms

X Zhan, N Li, X Zhan, S Qian - Med One, 2018 - hapres.com
Two-dimensional gel electrophoresis coupled with liquid chromatography/mass
spectrometry (2DE-LC/MS) is a classic and conventional approach to separate and identify …

[HTML][HTML] Comparative and quantitative global proteomics approaches: an overview

B Deracinois, C Flahaut, S Duban-Deweer… - Proteomes, 2013 - mdpi.com
Proteomics became a key tool for the study of biological systems. The comparison between
two different physiological states allows unravelling the cellular and molecular mechanisms …

The use of proteomics for the assessment of clinical samples in research

S Aldred, MM Grant, HR Griffiths - Clinical biochemistry, 2004 - Elsevier
Proteomics, the analysis of expressed proteins, has been an important developing area of
research for the past two decades [Anderson, NG, Anderson, NL. Twenty years of two …

Discovery of biomarker candidates within disease by protein profiling: principles and concepts

G Marko-Varga, H Lindberg, CG Löfdahl… - Journal of proteome …, 2005 - ACS Publications
Proteins and peptides present within clinical samples represent a valuable library of
information regarding the ongoing processes within cells and tissues in health and disease …

Mass spectrometry based proteomics, background, status and future needs

P Roepstorff - Protein & cell, 2012 - academic.oup.com
An overview of the background for proteomics and a description of the present state of art
are given with a description of the main strategies in proteomics. The advantages and …

The application of clinical proteomics to cancer and other diseases

W Clarke, Z Zhang, DW Chan - 2003 - degruyter.com
The term “clinical proteomics” refers to the application of available proteomics technologies
to current areas of clinical investigation. The ability to simultaneously and comprehensively …

Towards clinical proteomics analysis

K Imai, A Koshiyama, K Nakata - Biomedical Chromatography, 2011 - Wiley Online Library
To understand accurate protein dynamics, a highly reproducible proteomics analytical
method is required. The acquired thus knowledge will lead to the diagnosis, treatment and …

Differential proteomics: an overview of gel and non-gel based approaches

L Monteoliva, JP Albar - Briefings in Functional Genomics, 2004 - academic.oup.com
The comprehensive analysis of gene expression in complex biological systems has
demanded the development of new technologies to study the cell transcriptome and the cell …