[HTML][HTML] Proteomics: challenges, techniques and possibilities to overcome biological sample complexity
K Chandramouli, PY Qian - Human genomics and proteomics: HGP, 2009 - ncbi.nlm.nih.gov
Proteomics is the large-scale study of the structure and function of proteins in complex
biological sample. Such an approach has the potential value to understand the complex …
biological sample. Such an approach has the potential value to understand the complex …
Generally detected proteins in comparative proteomics–a matter of cellular stress response?
P Wang, FG Bouwman, ECM Mariman - Proteomics, 2009 - Wiley Online Library
2-DE in combination with MS is a widely used proteomic technology platform in comparative
protein profiling studies for the identification of biomarkers for specific conditions (eg …
protein profiling studies for the identification of biomarkers for specific conditions (eg …
Protein species as diagnostic markers
P Steffen, M Kwiatkowski, WD Robertson… - Journal of …, 2016 - Elsevier
Many diseases are associated with protein species perturbations. A prominent example of
an established diagnostic marker is the glycated protein species of hemoglobin, termed …
an established diagnostic marker is the glycated protein species of hemoglobin, termed …
Applications of proteomics in pharmaceutical research and development
H Yokota - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2019 - Elsevier
The significance of proteomics in the pharmaceutical industry has increased since
overcoming initial difficulties. This review discusses recent proteomics publications from …
overcoming initial difficulties. This review discusses recent proteomics publications from …
[HTML][HTML] Proteomics in pathology research
MS Lim, KSJ Elenitoba-Johnson - Laboratory Investigation, 2004 - Elsevier
Proteomics is a multifaceted approach to study various aspects of protein expression, post-
translational modification, interactions, organization and function at a global level. While …
translational modification, interactions, organization and function at a global level. While …
Limitations of current proteomics technologies
S Garbis, G Lubec, M Fountoulakis - Journal of Chromatography A, 2005 - Elsevier
Application of proteomics technologies in the investigation of biological systems creates new
possibilities in the elucidation of biopathomechanisms and the discovery of novel drug …
possibilities in the elucidation of biopathomechanisms and the discovery of novel drug …
A fast method for quantitative proteomics based on a combination between two‐dimensional electrophoresis and 15N‐metabolic labelling
APL Snijders, MGJ de Vos, B de Koning… - …, 2005 - Wiley Online Library
We provide a method for accurate protein quantitation that uses two‐dimensional (2‐D) gel
electrophoresis for protein separation, but does not require extensive statistical analysis of …
electrophoresis for protein separation, but does not require extensive statistical analysis of …
Multidimensional proteomics of human serum using parallel chromatography of native constituents and microplate technology
A Horn, S Kreusch, R Bublitz, H Hoppe… - …, 2006 - Wiley Online Library
A versatile, multidimensional, and non‐denaturing proteome separation procedure using
microplate technology is presented, yielding a digitized image of proteome composition. In …
microplate technology is presented, yielding a digitized image of proteome composition. In …
Proteomics: technologies and applications
MP Molloy, FA Witzmann - Briefings in Functional Genomics, 2002 - academic.oup.com
Enabling technologies for proteomics (studies examining the protein complement of the
genome) have been in development for over 20 years. However, more recently, the field has …
genome) have been in development for over 20 years. However, more recently, the field has …
Broad‐based proteomic strategies: a practical guide to proteomics and functional screening
DRM Graham, ST Elliott… - The Journal of physiology, 2005 - Wiley Online Library
Proteomics, the study of the proteome (the collection of all the proteins expressed from the
genome in all isoforms, polymorphisms and post‐translational modifications), is a rapidly …
genome in all isoforms, polymorphisms and post‐translational modifications), is a rapidly …