BACKGROUND: Stem cells are mainly characterized by two properties: self-renewal and the
potency to differentiate into diverse cell types. These processes are regulated by different …

The functional versatility of Wnt/β-catenin signaling can be seen by its ability to act in stem
cells of the embryo and of the adult as well as in cancer stem cells. During embryogenesis …

The intestinal epithelium represents a very attractive experimental model for the study of
integrated key cellular processes such as proliferation and differentiation. The tissue is …

Adult stem cells self-renew and replenish differentiated cells in various organs and tissues
throughout a mammal's life. Over the last 25 years an ever-growing body of knowledge has …

Signaling initiated by secreted glycoproteins of the Wnt family regulates many aspects of
embryonic development and it is involved in homeostasis of adult tissues. In the …

Tissue homeostasis is crucial for multicellular organisms, wherein the loss of cells is
compensated by generating new cells with the capacity for proliferation and differentiation …

Wnt signaling plays an important role in development and disease. In this review we focus
on the role of the canonical Wnt signaling pathway in somatic stem cell biology and its …

Wnt signaling determines major developmental processes in the embryonic state and
regulates maintenance, self-renewal and differentiation of adult mammalian tissue stem …

WNT signalling has been studied primarily in developing embryos, in which cells respond to
WNTs in a context-dependent manner through changes in survival and proliferation, cell fate …

Wnt signalling regulates several cellular functions including proliferation, differentiation,
apoptosis and migration, and is critical for embryonic development. Stem cells are defined …