[HTML][HTML] Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology
Background Alzheimer's disease (AD) is a chronic neurodegenerative disease with
pathological hallmarks including the formation of extracellular aggregates of amyloid-beta …
pathological hallmarks including the formation of extracellular aggregates of amyloid-beta …
[HTML][HTML] Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and …
E Castillo, J Leon, G Mazzei, N Abolhassani… - Scientific reports, 2017 - nature.com
Alzheimer's disease (AD) is the most common form of dementia, characterized by
accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and …
accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and …
Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer's disease
The linear cause-consequence relationship linking amyloid-β peptide (Aβ) accumulation to
neuronal dysfunction in Alzheimer disease (AD) is gradually replaced by the concept that Aβ …
neuronal dysfunction in Alzheimer disease (AD) is gradually replaced by the concept that Aβ …
[HTML][HTML] Differences in immune-related genes underlie temporal and regional pathological progression in 3xTg-AD mice
A Fernandes, C Caldeira, C Cunha, E Ferreiro, AR Vaz… - Cells, 2022 - mdpi.com
The prevalence of Alzheimer's disease (AD), the most common cause of age-associated
dementia, is estimated to increase over the next decades. Evidence suggests neuro-immune …
dementia, is estimated to increase over the next decades. Evidence suggests neuro-immune …
[HTML][HTML] A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies
Microglial dysfunction has been proposed as one of the many cellular mechanisms that can
contribute to the development of Alzheimer's disease (AD). Here, using a transcriptional …
contribute to the development of Alzheimer's disease (AD). Here, using a transcriptional …
Staging Alzheimer's disease in the brain and retina of B6. APP/PS1 mice by transcriptional profiling
SR Chintapaludi, A Uyar, HM Jackson… - Journal of …, 2020 - content.iospress.com
Alzheimer's disease (AD) is a common form of dementia characterized by amyloid plaque
deposition, tau pathology, neuroinflammation, and neurodegeneration. Mouse models …
deposition, tau pathology, neuroinflammation, and neurodegeneration. Mouse models …
[HTML][HTML] Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice
Peripheral inflammation has been linked to various neurodegenerative disorders, including
Alzheimer's disease (AD). Here we perform bulk, single-cell, and spatial transcriptomics in …
Alzheimer's disease (AD). Here we perform bulk, single-cell, and spatial transcriptomics in …
Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets
Alzheimer's disease (AD), the most common form of dementia, is recognized as a
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
[HTML][HTML] An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer's brains
The dominant risk factors for late-onset Alzheimer's disease (AD) are advanced age and the
APOE4 genetic variant. To examine how these factors alter neuroimmune function, we …
APOE4 genetic variant. To examine how these factors alter neuroimmune function, we …
[HTML][HTML] The neuroimmune axis of Alzheimer's disease
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …