Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis

JW Daily, S Kang, S Park - Biofactors, 2021 - Wiley Online Library
Luteolin is a widely distributed flavone herbs and vegetables. It has anti‐oxidant and anti‐
inflammatory activities and improves glucose metabolism by potentiating insulin sensitivity …

Bioavailability and pharmaco-therapeutic potential of luteolin in overcoming Alzheimer's disease

F Ali, YH Siddique - … (Formerly Current Drug Targets-CNS & …, 2019 - ingentaconnect.com
Luteolin is a naturally occurring, yellow crystalline flavonoid found in numerous dietary
supplements we frequently have in our meals. Studies in the last 2 decades have revealed …

The combination of luteolin and l-theanine improved Alzheimer disease–like symptoms by potentiating hippocampal insulin signaling and decreasing …

S Park, DS Kim, S Kang, HJ Kim - Nutrition research, 2018 - Elsevier
Luteolin and l-theanine have anti-inflammatory, antioxidant, and possible antidiabetic
activities, and they may synergistically protect against dementia. Here, we hypothesized that …

Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease

Y Kwon - Experimental Gerontology, 2017 - Elsevier
Amyloid cascade hypothesis is the main theoretical framework describing the development
of Alzheimer's disease (AD). However, most clinical trials of therapy targeting amyloid-β …

Luteolin as an anti-inflammatory and neuroprotective agent: A brief review

SF Nabavi, N Braidy, O Gortzi, E Sobarzo-Sanchez… - Brain research …, 2015 - Elsevier
Abstract According to the World Health Organization, two billion people will be aged 60
years or older by 2050. Aging is a major risk factor for a number of neurodegenerative …

[HTML][HTML] Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice

S Jang, RN Dilger, RW Johnson - The Journal of nutrition, 2010 - Elsevier
A dysregulated overexpression of inflammatory mediators by microglia may facilitate
cognitive aging and neurodegeneration. Considerable evidence suggests the flavonoid …

Luteolin protects against high fat diet-induced cognitive deficits in obesity mice

Y Liu, X Fu, N Lan, S Li, J Zhang, S Wang, C Li… - Behavioural brain …, 2014 - Elsevier
The epidemic and experimental studies have confirmed that the obesity can lead to
neuroinflammation, neurodegenerative diseases and adversely affect cognition. Despite the …

Deciphering the Potential Neuroprotective Effects of Luteolin against Aβ142-Induced Alzheimer's Disease

S Ahmad, MH Jo, M Ikram, A Khan, MO Kim - International Journal of …, 2021 - mdpi.com
The current study was undertaken to unveil the protective effects of Luteolin, a natural
flavonoid, against amyloid-beta (Aβ1–42)-induced neuroinflammation, amyloidogenesis …

Luteolin attenuates diabetes-associated cognitive decline in rats

Y Liu, X Tian, L Gou, L Sun, X Ling, X Yin - Brain Research Bulletin, 2013 - Elsevier
Diabetes mellitus can cause dysfunction of the central nervous system called “diabetic
encephalopathy”. Although various oral drugs are used to treat diabetes, they do not prevent …

[HTML][HTML] Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ …

Z He, X Li, Z Wang, Y Cao, S Han, N Li, J Cai, S Cheng… - Redox Biology, 2023 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by the
deposition of β-amyloid (Aβ) peptides and dysfunction of mitochondrion, which result in …