More than 1.5 billion people experience declining hearing ability during their lifetime. With
an aging population and increased exposure to excessive noise, there has never been a …

The sense of hearing enables us to enjoy sounds and music and engage with other people.
The sense of hearing is, however, vulnerable to environmental challenges, such as …

Abstract Digenic Connexin26 (Cx26, GJB2) and Cx30 (GJB6) heterozygous mutations are
the second most frequent cause of recessive deafness in humans. However, the underlying …

Normal development, function and repair of the sensory epithelia in the inner ear are all
dependent on gap junctional intercellular communication. Mutations in the connexin genes …

Gjb2 and Gjb6, two contiguous genes respectively encoding the gap junction protein
connexin26 (Cx26) and connexin 30 (Cx30) display overlapping expression in the inner ear …

Intercellular communication via gap junctions is crucial for auditory function. This has been
emphasized by the findings that mutations in certain connexin genes, in particular GJB2 and …

Sensorineural hearing loss (SNHL) affects approximately 466 million people worldwide,
which is projected to reach 900 million by 2050. Its histological characteristics are lesions in …

Connexin26 (Cx26, encoded by GJB2) mutations are the most common cause of non-
syndromic deafness. GJB2 is thought to be involved in noise-induced hearing loss (NIHL) …

Sensorineural hearing loss (SNHL), a multifactorial progressive disorder, results from a
complex interplay of genetic and environmental factors, with its underlying mechanisms …

A number of genes responsible for hearing loss are related to ion recycling and homeostasis
in the inner ear. Connexins (Cx26 encoded by GJB2, Cx31 encoded by GJB3 and Cx30 …