What do we know about the role of lipoprotein (a) in atherogenesis 57 years after its discovery?

B Cybulska, L Kłosiewicz-Latoszek, PE Penson… - Progress in …, 2020 - Elsevier
Elevated circulating concentrations of lipoprotein (a)[Lp (a)] is strongly associated with
increased risk of atherosclerotic cardiovascular disease (CVD) and degenerative aortic …

Lipoprotein (a) and Cardiovascular Diseases―Revisited―

AY Jang, SH Han, IS Sohn, PC Oh, KK Koh - Circulation Journal, 2020 - jstage.jst.go.jp
Two decades ago, it was recognized that lipoprotein (a)(Lp (a)) concentrations were
elevated in patients with cardiovascular disease (CVD). However, the importance of Lp (a) …

Lipoprotein (a): evidence for role as a causal risk factor in cardiovascular disease and emerging therapies

HS Bhatia, MJ Wilkinson - Journal of clinical medicine, 2022 - mdpi.com
Lipoprotein (a)(Lp (a)) is an established risk factor for multiple cardiovascular diseases.
Several lines of evidence including mechanistic, epidemiologic, and genetic studies support …

Elevated lipoprotein (a) and risk of ischemic stroke

A Langsted, BG Nordestgaard, PR Kamstrup - Journal of the American …, 2019 - jacc.org
Background: High lipoprotein (a) is associated with increased risk of myocardial infarction
and aortic valve stenosis. Previous studies have examined the association of lipoprotein (a) …

Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein (a) level elevation in African Americans compared with European …

JP Chretien, J Coresh, Y Berthier-Schaad… - Journal of medical …, 2006 - jmg.bmj.com
Background: The extent which universally common or population-specific alleles can
explain between-population variations in phenotypes is unknown. The heritable coronary …

Ancestry, Lipoprotein(a), and Cardiovascular Risk Thresholds: JACC Review Topic of the Week

S Tsimikas, SM Marcovina - Journal of the American College of Cardiology, 2022 - jacc.org
This study reviews ancestral differences in the genetics of the LPA gene, risk categories of
elevated lipoprotein (a)[Lp (a)] as defined by guidelines, ancestry-specific Lp (a) risk …

Elevated lipoprotein (a)—a genetic risk factor for premature vascular disease in people with and without standard risk factors: a review

EA Enas, V Chacko, A Senthilkumar, N Puthumana… - Disease-a-Month, 2006 - Elsevier
Lp (a) was identified as a novel antigen by Kare Berg in 1963. 1 Mounting evidence from
prospective epidemiologic and clinical studies over the past four decades show that …

Lipoprotein (a) concentration and risks of cardiovascular disease and diabetes

DF Gudbjartsson, G Thorgeirsson, P Sulem… - Journal of the American …, 2019 - jacc.org
Abstract Background: Lipoprotein (a)[Lp (a)] is a causal risk factor for cardiovascular
diseases that has no established therapy. The attribute of Lp (a) that affects cardiovascular …

Apolipoprotein (a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

A Helgadottir, S Gretarsdottir, G Thorleifsson… - Journal of the American …, 2012 - jacc.org
Objectives: The purpose of this study is investigate the effects of variants in the
apolipoprotein (a) gene (LPA) on vascular diseases with different atherosclerotic and …

Relations between lipoprotein (a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and …

S Zewinger, ME Kleber, V Tragante… - The lancet Diabetes & …, 2017 - thelancet.com
Background Lipoprotein (a) concentrations in plasma are associated with cardiovascular
risk in the general population. Whether lipoprotein (a) concentrations or LPA genetic …