Cardiac scars, often dubbed 'dead tissue', are very much alive, with heterocellular activity
contributing to the maintenance of structural and mechanical integrity following heart injury …

Infarct scar tissue has long been considered inert (acellular, composed simply of fibrillar
collagen) and whose function is simply to restore structural integrity to infarcted myocardium …

In the adult, tissue repair after injury is generally compromised by fibrosis, which maintains
tissue integrity with scar formation but does not restore normal architecture and function. The …

Once myocardium dies during a heart attack, it is replaced by scar tissue over the course of
several weeks. The size, location, composition, structure and mechanical properties of the …

Myocardial infarction (MI) is a major source of morbidity and mortality worldwide, with over 7
million people suffering infarctions each year. Heart muscle damaged during MI is replaced …

Cardiac fibroblasts are the most abundant cell type in the mammalian heart and comprise
approximately two-thirds of the total number of cardiac cell types. During development …

Myocardial scar formation impairs heart function by inducing cardiac remodeling,
decreasing myocardial compliance, and compromising normal electrical conduction …

Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate
acute wound healing and long-term tissue remodeling with scarring. With myocardial …

Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue
deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart …

In vitro cardiac models able to mimic the fibrotic process are paramount to develop an
effective anti-fibrosis therapy that can regulate fibroblast behaviour upon myocardial injury …