Nanoparticle amplification labeling for high-performance magnetic cell sorting

Z Wang, H Wang, S Lin, S Ahmed, S Angers… - Nano …, 2022 - ACS Publications
Magnetic cell sorting is an enabling tool for the isolation of specific cellular subpopulations
for downstream applications and requires the cells to be labeled by a sufficient number of …

Magnetic‐nanoparticle‐based immunoassays‐on‐chip: materials synthesis, surface functionalization, and cancer cell screening

Y Zhu, K Kekalo, C NDong, YY Huang… - Advanced Functional …, 2016 - Wiley Online Library
The unique properties of magnetic nanoparticles (MNPs), coupled with versatile surface
engineering techniques, have led to a rising class of screening methods that enable …

Engineering magnetic nanoparticles and their integration with microfluidics for cell isolation

M Unni, J Zhang, TJ George, MS Segal, ZH Fan… - Journal of colloid and …, 2020 - Elsevier
Isolation of cancer cells, bacteria, and viruses from peripheral blood has important
applications in cancer diagnosis, therapy monitoring, and drug development. Magnetic …

Magnetic-activated cell sorting using coiled-coil peptides: an alternative strategy for isolating cells with high efficiency and specificity

MJ Shen, RCL Olsthoorn, Y Zeng… - … applied materials & …, 2021 - ACS Publications
Magnetic-activated cell sorting (MACS) is an affinity-based technique used to separate cells
according to the presence of specific markers. Current MACS systems generally require an …

Microscale magnetic field modulation for enhanced capture and distribution of rare circulating tumor cells

P Chen, YY Huang, K Hoshino, JXJ Zhang - Scientific reports, 2015 - nature.com
Immunomagnetic assay combines the powers of the magnetic separation and biomarker
recognition and has been an effective tool to perform rare Circulating Tumor Cells detection …

Multitarget magnetic activated cell sorter

JD Adams, U Kim, HT Soh - Proceedings of the National …, 2008 - National Acad Sciences
Magnetic selection allows high-throughput sorting of target cells based on surface markers,
and it is extensively used in biotechnology for a wide range of applications from in vitro …

Versatile immunomagnetic nanocarrier platform for capturing cancer cells

CH Wu, YY Huang, P Chen, K Hoshino, H Liu… - ACS …, 2013 - ACS Publications
Sensitive and quantitative assessment of changes in circulating tumor cells (CTCs) can help
in cancer prognosis and in the evaluation of therapeutics efficacy. However, extremely low …

Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting

M Labib, Z Wang, SU Ahmed, RM Mohamadi… - Nature biomedical …, 2021 - nature.com
Molecular-level features of tumours can be tracked using single-cell analyses of circulating
tumour cells (CTCs). However, single-cell measurements of protein expression for rare …

Rare cell analysis after negative selection

M Samuels, DR Link - US Patent App. 14/245,348, 2014 - Google Patents
BACKGROUND 0003. Analysis of rare cells (eg Circulating Tumor Cells, CTCs) requires
challenging and limited methods of positive cell selection resulting in very few cells (5-50 …

Magnetic separation of acoustically focused cancer cells from blood for magnetographic templating and analysis

CW Shields IV, JL Wang, KA Ohiri, ED Essoyan… - Lab on a Chip, 2016 - pubs.rsc.org
Liquid biopsies hold enormous promise for the next generation of medical diagnoses. At the
forefront of this effort, many are seeking to capture, enumerate and analyze circulating tumor …