Glioblastoma (GBM) is one of the deadliest forms of cancer. Despite many treatment options,
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …

Angiogenesis, the formation of new blood vessels, is an essential process for tumour
progression and is an area of significant therapeutic interest. Different in vitro systems and …

In vitro cell-based models of lung cancer are frequently employed to study invasion and the
mechanisms behind metastasis. However, these models often study only one cell type with …

Hyperpermeable tumor vessels are responsible for elevated interstitial fluid pressure and
altered flow patterns within the tumor microenvironment. These aberrant hydrodynamic …

Glioblastoma (GBM) angiogenesis is critical for tumor growth and recurrence, making it a
compelling therapeutic target. Here, a disease-relevant, vascularized tumoroid in vitro model …

Oxygen status and tissue dimensionality are critical determinants of tumor angiogenesis, a
hallmark of cancer and an enduring target for therapeutic intervention. However, it is unclear …

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading
cause of cancer worldwide. Despite approvals of several therapeutics to treat advanced …

This study addresses establishment of an “in vitro” melanoma angiogenesis model using
multicellular tumor spheroids (MCTS) of differentiated (HBL) or undifferentiated (NA8) …

Here, we demonstrate the flexibility of peptide-functionalized poly (ethylene glycol)(PEG)
hydrogels for modeling tumor progression. The PEG hydrogels were formed using thiol-ene …

A major challenge in the development of cancer nanomedicine is the inability for
nanomaterials to efficiently penetrate and deliver therapeutic agents into solid tumors …