Uveitis is a heterogeneous collection of diseases with polygenic and environmental
influences. This heterogeneity presents challenges in trial design and selection of end …

Background Endogenous uveitis is a sight-threatening disease. In addition to
corticosteroids, immunosuppressive agents are commonly used to treat patients with severe …

With the increase in our understanding of the immunopathogenic mechanisms of uveitis, we
are now able to generate more specific immunebased therapies. 1 In this chapter I discuss …

Ocular inflammatory disease is a leading cause of vision loss worldwide. Uveitis
encompasses a wide spectrum of pathology, both with respect to its etiology and the …

Uveitis is a sight threatening inflammatory disorder that affects all ages and remains a
significant cause of visual loss. Animal models of autoimmune and inflammatory disease in …

Treatment of inflammatory diseases of the eye is especially challenging. Although
physicians in antiquity had recognized the existence of ocular inflammatory disease, their …

Autoimmune uveitis is an organ-specific disorder characterized by irreversible lesions to the
eye that predominantly affect people in their most productive years and is among the leading …

Introduction: The conventional treatment of uveitis includes corticosteroids and
immunosuppressive agents, which are highly efficacious, but can be associated with serious …

The management of complex uveitis is often based around the use of oral corticosteroids. To
spare the side effects of corticosteroids, second-line oral immunosuppressant drugs are …

Autoimmune uveitis is a complex group of sight-threatening diseases that arise without a
known infectious trigger. The disorder is often associated with immunological responses to …