Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes
A Scotto d'Abusco, V Calamia, C Cicione… - Arthritis research & …, 2007 - Springer
The aim of this study was to determine the effects of glucosamine on matrix metalloprotease
(MMP) production, on mitogen-activated protein kinase (MAPK) phosphorylation, and on …
(MMP) production, on mitogen-activated protein kinase (MAPK) phosphorylation, and on …
Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways
YC Lin, YC Liang, MT Sheu, YC Lin, MS Hsieh… - Rheumatology …, 2008 - Springer
The purpose of the present study was to elucidate the possible signal transduction pathway
involved in the underlying mechanism of glucosamine (GLN)'s influence on the gene …
involved in the underlying mechanism of glucosamine (GLN)'s influence on the gene …
Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine
N Ivanovska, P Dimitrova - Arthritis research & therapy, 2011 - Springer
Introduction Glucosamine is an amino-monosaccharide and precursor of
glycosaminoglycans, major components of joint cartilage. Glucosamine has been clinically …
glycosaminoglycans, major components of joint cartilage. Glucosamine has been clinically …
Disease‐modifying effects of Glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin‐1β in human primary synovial …
HT Lu, YC Liang, MT Sheu, HO Ho… - Journal of cellular …, 2008 - Wiley Online Library
The purpose of this study was to investigate the possible involvement of synovium in
cartilage destruction in osteoarthritis (OA) patients. Using human primary synovial fibroblasts …
cartilage destruction in osteoarthritis (OA) patients. Using human primary synovial fibroblasts …
Matrix metalloproteinase-3 induces proteoglycan degradation in gouty arthritis model
L Shi, T Liang, F Yang, FF Zhu, J Liu, JQ Jiang, XW Wu… - Gene, 2021 - Elsevier
Background Gout is an inflammatory arthritis resulting from precipitation of monosodium
urate (MSU) crystals in joints and surrounding tissues. However, the mechanism underlying …
urate (MSU) crystals in joints and surrounding tissues. However, the mechanism underlying …
Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1β
JN Gouze, E Gouze, MP Popp, ML Bush… - Arthritis research & …, 2006 - Springer
The effects of exogenous glucosamine on the biology of articular chondrocytes were
determined by examining global transcription patterns under normal culture conditions and …
determined by examining global transcription patterns under normal culture conditions and …
Glucosamine sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis
SC Chu, SF Yang, KH Lue, YS Hsieh, CY Lee… - Clinica chimica acta, 2006 - Elsevier
BACKGROUND: Glucosamine sulfate may have an ex vivo inhibitory effect on the
plasminogen activator (PA)/plasmin system and gelatinases expression during the early …
plasminogen activator (PA)/plasmin system and gelatinases expression during the early …
Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-κB) transcription factors down-regulates matrix …
A Liacini, J Sylvester, WQ Li, M Zafarullah - Matrix Biology, 2002 - Elsevier
Interleukin-1 (IL-1), the main cytokine instigator of cartilage degeneration in arthritis, induces
matrix metalloproteinase-3 (MMP-3) and MMP-13 RNA and protein in chondrocytes. The …
matrix metalloproteinase-3 (MMP-3) and MMP-13 RNA and protein in chondrocytes. The …
Glucosamine modulates IL‐1‐induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF‐κB pathway
JN Gouze, A Bianchi, P Becuwe, M Dauca… - FEBS …, 2002 - Wiley Online Library
We recently reported that glucosamine reversed the decrease in proteoglycan synthesis and
in UDP‐glucuronosyltransferase I mRNA expression induced by interleukin‐1β (IL …
in UDP‐glucuronosyltransferase I mRNA expression induced by interleukin‐1β (IL …
Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase …
Z Rasheed, AN Anbazhagan, N Akhtar… - Arthritis research & …, 2009 - Springer
Introduction The major risk factor for osteoarthritis (OA) is aging, but the mechanisms
underlying this risk are only partly understood. Age-related accumulation of advanced …
underlying this risk are only partly understood. Age-related accumulation of advanced …