Microfluidic analysis of red blood cell deformability

Q Guo, SP Duffy, K Matthews, AT Santoso… - Journal of …, 2014 - Elsevier
A common indicator of rheological dysfunction is a measurable decrease in the deformability
of red blood cells (RBCs). Decreased RBC deformability is associated with cellular stress or …

Biomechanical properties of red blood cells in health and disease towards microfluidics

G Tomaiuolo - Biomicrofluidics, 2014 - pubs.aip.org
Red blood cells (RBCs) possess a unique capacity for undergoing cellular deformation to
navigate across various human microcirculation vessels, enabling them to pass through …

Advances in the measurement of red blood cell deformability: A brief review

J Kim, HY Lee, S Shin - Journal of Cellular Biotechnology, 2015 - content.iospress.com
Red blood cells (RBCs) exhibit a unique deformability, which enables them to change shape
reversibly in response to an external force. The deformability of RBCs allows them to flow in …

Alterations in red blood cell deformability during storage: a microfluidic approach

JCA Cluitmans, V Chokkalingam… - BioMed Research …, 2014 - Wiley Online Library
Red blood cells (RBCs) undergo extensive deformation when travelling through the
microcapillaries. Deformability, the combined result of properties of the membrane …

Mechanical signature of red blood cells flowing out of a microfluidic constriction is impacted by membrane elasticity, cell surface-to-volume ratio and diseases

M Faivre, C Renoux, A Bessaa, L Da Costa… - Frontiers in …, 2020 - frontiersin.org
Despite the fact that Red Blood Cells (RBCs) have been intensively studied in the past 50
years to characterize mechanical phenotypes associated with both healthy and pathological …

Theoretical model and experimental study of red blood cell (RBC) deformation in microchannels

N Korin, A Bransky, U Dinnar - Journal of biomechanics, 2007 - Elsevier
The motion and deformation of red blood cells (RBCs) flowing in a microchannel were
studied using a theoretical model and a novel automated rheoscope. The theoretical model …

Technologies for measuring red blood cell deformability

K Matthews, ES Lamoureux, ME Myrand-Lapierre… - Lab on a Chip, 2022 - pubs.rsc.org
Human red blood cells (RBCs) are approximately 8 μm in diameter, but must repeatedly
deform through capillaries as small as 2 μm in order to deliver oxygen to all parts of the …

Mechanical response of red blood cells entering a constriction

NF Zeng, WD Ristenpart - Biomicrofluidics, 2014 - pubs.aip.org
Most work on the dynamic response of red blood cells (RBCs) to hydrodynamic stress has
focused on linear velocity profiles. Relatively little experimental work has examined how …

Microfluidic deformability analysis of the red cell storage lesion

K Matthews, ME Myrand-Lapierre, RR Ang… - Journal of …, 2015 - Elsevier
A key challenge in transfusion medicine research and clinical hematology is to develop a
simple and non-destructive method to measure the quality of each blood unit prior to use …

A system for the high-throughput measurement of the shear modulus distribution of human red blood cells

A Saadat, DA Huyke, DI Oyarzun, PV Escobar… - Lab on a Chip, 2020 - pubs.rsc.org
Reduced deformability of red blood cells (RBCs) can affect the hemodynamics of the
microcirculation and reduce oxygen transport efficiency. It is also well known that reduced …