Pharmacological activity of cepharanthine

K Liu, B Hong, S Wang, F Lou, Y You, R Hu, A Shafqat… - Molecules, 2023 - mdpi.com
Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant
Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for …

Pharmacological effects and clinical prospects of cepharanthine

D Liang, Q Li, L Du, G Dou - Molecules, 2022 - mdpi.com
Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha
Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has …

Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

C Bailly - Phytomedicine, 2019 - Elsevier
Background Cepharanthine (CEP) is a drug used in Japan since the 1950s to treat a
number of acute and chronic diseases, including treatment of leukopenia, snake bites …

Cepharanthine: A review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19

M Rogosnitzky, P Okediji, I Koman - Pharmacological Reports, 2020 - Springer
Cepharanthine (CEP) is a naturally occurring alkaloid derived from Stephania cepharantha
Hayata and demonstrated to have unique anti-inflammatory, antioxidative …

Determination of cepharanthine in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

Y Deng, W Wu, S Ye, W Wang, Z Wang - Pharmaceutical biology, 2017 - Taylor & Francis
Context: Cepharanthine (CPA) has been reported to possess a wide range of
pharmacological activities. Objective: This study investigates the pharmacokinetic …

[HTML][HTML] Unraveling the mechanism of action of cepharanthine for the treatment of novel coronavirus pneumonia (COVID-19) from the perspectives of systematic …

F Sun, J Liu, A Tariq, Z Wang, Y Wu, L Li - Arabian Journal of Chemistry, 2023 - Elsevier
Natural products play an irreplaceable role in the treatment of SARS-CoV-2 infection.
Nevertheless, the underlying molecular mechanisms involved remain elusive. To better …

The brief overview, antivirus and anti-SARS-CoV-2 activity, quantitative methods, and pharmacokinetics of cepharanthine: a potential small-molecule drug against …

B Xia, L Zheng, Y Li, W Sun, Y Liu, L Li… - Frontiers in …, 2023 - frontiersin.org
To effectively respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
an increasing number of researchers are focusing on the antiviral activity of cepharanthine …

Pharmacokinetic disposition of cepharanthin following single and multiple intravenous doses in healthy subjects

K YASUDA, M MORO, M AKASU… - Rinsho yakuri/Japanese …, 1989 - jstage.jst.go.jp
The pharmacokinetic disposition of Cepharanthin, a biscoclaurine alkaloid, was investigated
in healthy subjects following single intravenous doses of 25, 50, and 100mg and during and …

Simple, sensitive and rapid HPLC–MS/MS method for the determination of cepharanthine in human plasma

G Hao, H Liang, Y Li, H Li, H Gao, G Liu… - Journal of Chromatography …, 2010 - Elsevier
A rapid, sensitive and specific method for the determination of cepharanthine in human
plasma using high performance liquid chromatography coupled with tandem mass …

Cepharanthine: A Promising Old Drug against SARS‐CoV‐2

H Fan, S He, P Han, B Hong, K Liu, M Li… - Advanced …, 2022 - Wiley Online Library
Recently, the inhibiting effects of a clinically approved drug Cepharanthine on severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) have attracted widespread attention and …