“Natural” presentation of human papillomavirus type‐16 E7 protein to immunocompetent mice results in antigen‐specific sensitization or sustained unresponsiveness
MA Chambers, Z Wei, N Coleman… - European journal of …, 1994 - Wiley Online Library
We have used a mouse model that utilizes the exclusively epithelial nature of human
papillomavirus (HPV) infections to investigate the in vivo immune response to the E7 protein …
papillomavirus (HPV) infections to investigate the in vivo immune response to the E7 protein …
Delayed-type hypersensitivity response to human papillomavirus type 16 E6 protein in a mouse model
MA Chambers, SN Stacey… - Journal of general …, 1994 - microbiologyresearch.org
A mouse model incorporating the epitheliotropic nature of human papillomavirus (HPV)
infections has been used to study an immune response to HPV type 16 (HPV-16) E6 protein …
infections has been used to study an immune response to HPV type 16 (HPV-16) E6 protein …
Delayed-type hypersensitivity response to the human papillomavirus type 16 E7 protein in a mouse model
CS McLean, JS Sterling, J Mowat… - Journal of General …, 1993 - microbiologyresearch.org
To study the immune response to human papillomavirus type 16, a mouse model was
developed using a mouse keratinocyte cell line expressing the E7 protein. This line was …
developed using a mouse keratinocyte cell line expressing the E7 protein. This line was …
E7-specific cytotoxic T cell tolerance in HPV-transgenic mice
A Borchers, J Braspenning, J Meijer, W Osen… - Archives of …, 1999 - Springer
The “high-risk” human papillomavirus type 16 (HPV 16) is associated with the development
of cervical cancer. Although the viral gene products E6 and E7 are constitutively expressed …
of cervical cancer. Although the viral gene products E6 and E7 are constitutively expressed …
Low level expression of human papillomavirus type 16 (HPV16) E6 in squamous epithelium does not elicit E6 specific B-or T-helper immunological responses, or …
R Azoury-Ziadeh, K Herd, GJP Fernando, P Lambert… - Virus Research, 2001 - Elsevier
Mice transgenic for E6/E7 oncogenes of Human Papillomavirus type 16 display life-long
expression of E6 in lens and skin epithelium, and develop inflammatory skin disease late in …
expression of E6 in lens and skin epithelium, and develop inflammatory skin disease late in …
E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B-or Th-repertoires or on the immune response …
A line of FVB (H-2q) mice transgenic for the E6/E7 open reading frames of Human
Papillomavirus type 16 driven from the α-A crystallin promoter expresses E7 mRNA in lens …
Papillomavirus type 16 driven from the α-A crystallin promoter expresses E7 mRNA in lens …
Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease
The human papillomavirus (HPV) oncogenes, E6 and E7, are believed to contribute to the
development of cervical cancers in women infected with certain HPV genotypes, most …
development of cervical cancers in women infected with certain HPV genotypes, most …
Effective Induction of Type 1 Helper IgG2a and Cytotoxic T-Cell Responses in Mice Following Immunization with Human Papillomavirus Type 16 E2 in MF59
L Heinemann, L Woodfield, M Amer, M Hibma - Viral Immunology, 2008 - liebertpub.com
Human papillomavirus (HPV) 16 E2–specific cell-mediated immunity to the early viral
antigen E2 is associated with regression of natural infection in patients with cervical …
antigen E2 is associated with regression of natural infection in patients with cervical …
Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16
I Melero, MC Singhal, P McGowan, HS Haugen… - Journal of …, 1997 - Am Soc Microbiol
Certain human papillomaviruses (HPV) have been implicated in the etiology of cervical
malignancies, and the E7 and E6 gene products of HPV type 16 are frequently expressed in …
malignancies, and the E7 and E6 gene products of HPV type 16 are frequently expressed in …
Cytokine profile of draining lymph node lymphocytes in mice grafted with syngeneic keratinocytes expressing human papillomavirus type 16 E7 protein
MC López, MA Stanley - Journal of General Virology, 2000 - microbiologyresearch.org
Studies on the immune response to human papillomaviruses are compromised by the
extreme host and tissue specificity of these viruses. To circumvent this, a mouse model …
extreme host and tissue specificity of these viruses. To circumvent this, a mouse model …