Emerging evidence shows that G protein-coupled receptors can form homo-and heteromers.
These include adenosine A2A receptor–dopamine D2 receptor heteromers, which are most …

The possible molecular basis for the previously described antagonistic interactions between
adenosine A1 receptors (A1R) and dopamine D1 receptors (D1R) in the brain have been …

Adenosine A2A and dopamine D2 receptors have been shown previously to form
heteromeric complexes and interact at the level of agonist binding, G protein coupling, and …

The existence of A 2A-D 2 heteromeric complexes is based on coimmunoprecipitation
studies and on fluorescence resonance energy transfer and bioluminescence resonance …

Adenosine A2A (A2AR) and dopamine D2 (D2R) receptors mediate the antagonism
between adenosinergic and dopaminergic transmission in striatopallidal GABAergic …

Adenosine A2A-dopamine D2 receptor interactions play a very important role in striatal
function. A2A-D2 receptor interactions provide an example of the capabilities of information …

Drug addiction is a serious brain disorder with somatic, psychological, psychiatric, socio-
economic and legal implications in the developed world. Illegal (eg, psychostimulants …

Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key
modulators of striatal neuronal function. It has been suggested that the psychostimulant …

Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel
targets for drug development. Accumulating evidence indicates that GPCRs can form …

Functional interactions between adenosine A 2A and dopamine D 2 receptors have been
demonstrated both at the D 2 agonist-binding and second messenger levels. The present …