[HTML][HTML] Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory …
AV Salnikov, L Liu, M Platen, J Gladkich, O Salnikova… - 2012 - journals.plos.org
Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion
and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de …
and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de …
[HTML][HTML] Conversion of epithelial-to-mesenchymal transition to mesenchymal-to-epithelial transition is mediated by oxygen concentration in pancreatic cancer cells …
Tumor metastasis is accompanied by a two‑stage process of epithelial-to-mesenchymal
transition (EMT) and mesenchymal-to-epithelial transition (MET). Currently, the exact …
transition (EMT) and mesenchymal-to-epithelial transition (MET). Currently, the exact …
Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells
O Hashimoto, K Shimizu, S Semba, S Chiba, Y Ku… - Pathobiology, 2011 - karger.com
Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …
[HTML][HTML] HIF-1α induces the epithelial-mesenchymal transition in gastric cancer stem cells through the Snail pathway
S Yang, Z Zhang, Y Hao, Y Zhao, F Qian, Y Shi, P Li… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Substantial evidence suggests that the epithelial-mesenchymal transition (EMT) phenotype
is associated with the invasive characteristics of cancer stem cells (CSCs), which possess …
is associated with the invasive characteristics of cancer stem cells (CSCs), which possess …
The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling
T Ide, Y Kitajima, A Miyoshi, T Ohtsuka… - Annals of surgical …, 2007 - Springer
Background Pancreatic cancer is one of the representative solid tumors, in which the
hypoxic microenvironment plays a crucial role in malignant progression. We previously …
hypoxic microenvironment plays a crucial role in malignant progression. We previously …
[HTML][HTML] Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem …
H Zhu, D Wang, Y Liu, Z Su, L Zhang, F Chen… - Cancer cell …, 2013 - Springer
The initiation and progression of various solid tumors, including pancreatic carcinoma, are
driven by a population of cells with stem cell properties, namely cancer stem cells (CSCs) …
driven by a population of cells with stem cell properties, namely cancer stem cells (CSCs) …
Tumor–stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c‐Met pathway
T Ide, Y Kitajima, A Miyoshi, T Ohtsuka… - … journal of cancer, 2006 - Wiley Online Library
The hypoxic environment in tumor is reported to play an important role in pancreatic cancer
progression. The interaction between stromal and cancer cells also contributes to the …
progression. The interaction between stromal and cancer cells also contributes to the …
[HTML][HTML] CD133 modulate HIF-1α expression under hypoxia in EMT phenotype pancreatic cancer stem-like cells
K Maeda, Q Ding, M Yoshimitsu, T Kuwahata… - International Journal of …, 2016 - mdpi.com
Although CD133 is a known representative cancer stem cell marker, its function in tumor
aggressiveness under hypoxia is not fully known. The aim of this study is to demonstrate that …
aggressiveness under hypoxia is not fully known. The aim of this study is to demonstrate that …
[HTML][HTML] Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
P Chaturvedi, DM Gilkes, CCL Wong… - The Journal of …, 2012 - Am Soc Clin Investig
Metastasis involves critical interactions between cancer and stromal cells. Intratumoral
hypoxia promotes metastasis through activation of hypoxia-inducible factors (HIFs). We …
hypoxia promotes metastasis through activation of hypoxia-inducible factors (HIFs). We …
[HTML][HTML] Direct cell-to-cell transfer in stressed tumor microenvironment aggravates tumorigenic or metastatic potential in pancreatic cancer
G Jang, J Oh, E Jun, J Lee, JY Kwon, J Kim… - NPJ Genomic …, 2022 - nature.com
Pancreatic cancer exhibits a characteristic tumor microenvironment (TME) due to enhanced
fibrosis and hypoxia and is particularly resistant to conventional chemotherapy. However …
fibrosis and hypoxia and is particularly resistant to conventional chemotherapy. However …