ABSTRACT A dense local vascular network is crucial for pancreatic endocrine cells to sense
metabolites and secrete hormones, and understanding the interactions between the …

The mechanisms underlying zebrafish pancreatic islet vascularization have not been well
characterized. We sought to determine the angiogenic factors responsible for islet …

Blood vessel networks provide nutrients and gaseous exchange that are essential for
functions. Pancreatic islet capillaries deliver oxygen to endocrine cells while transporting …

Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …

The vertebrate pancreas is comprised of a highly branched tubular epithelium, which is
intimately associated with an extensive and specialized vasculature. While we know a great …

Neurovascular alignment is a common anatomical feature of organs, but the mechanisms
leading to this arrangement are incompletely understood. Here, we show that vascular …

Pancreatic islets are innervated by autonomic and sensory nerves that influence their
function. Analyzing the innervation process should provide insight into the nerve-endocrine …

Pancreatic endocrine islets are vital for glucose homeostasis. However, the islet
developmental trajectory and its regulatory network are not well understood. To define the …

Blood vessels form a highly branched, interconnected, and largely stereotyped network of
tubes that sustains every organ and tissue in vertebrates. How vessels come to take on their …

How organ size and form are controlled during development is a major question in biology.
Blood vessels have been shown to be essential for early development of the liver and …