Localised delivery of quercetin by thermo-sensitive PLGA-PEG-PLGA hydrogels for the treatment of brachial plexus avulsion

C Huang, C Fu, ZP Qi, WL Guo, D You… - Artificial Cells …, 2020 - Taylor & Francis
Accumulating evidence indicates that oxidative stress and inflammation are implicated in
brachial plexus avulsion (BPA). Quercetin has anti-inflammatory, anti-oxidant, anti-apoptotic …

Nanoparticle technologies in the spinal cord

JM Zuidema, RJ Gilbert, DJ Osterhout - Cells Tissues Organs, 2016 - karger.com
Nanoparticles are increasingly being studied within experimental models of spinal cord
injury (SCI). They are used to image cells and tissue, move cells to specific regions of the …

Biomimetic electrospun PLLA/PPSB nanofibrous scaffold combined with human neural stem cells for spinal cord injury repair

Y Dai, W Wang, X Zhou, L li, Y Tang… - ACS Applied Nano …, 2023 - ACS Publications
Spinal cord injury (SCI) treatment remains a worldwide challenge considering its limited self-
repair capacity. The transplantation of neural stem cells (NSCs) has been proposed as a …

Graphene oxide-PLGA hybrid nanofibres for the local delivery of IGF-1 and BDNF in spinal cord repair

S Pan, Z Qi, Q Li, Y Ma, C Fu, S Zheng… - Artificial Cells …, 2019 - Taylor & Francis
Spinal cord injury (SCI) can lead to permanent and severe functional impairment below the
lesion level and is still one of the most challenging clinical problems. The treatment of SCI …

Encapsulation of Human Spinal Cord Progenitor Cells in Hyaluronan-Gelatin Hydrogel for Spinal Cord Injury Treatment

C Kwokdinata, V Ramanujam, J Chen… - … Applied Materials & …, 2023 - ACS Publications
Transplanting human induced pluripotent stem cells (iPSCs)-derived spinal cord progenitor
cells (SCPCs) is a promising approach to treat spinal cord injuries. However, stem cell …

Sustained delivery of dibutyryl cyclic adenosine monophosphate to the transected spinal cord via oligo [(polyethylene glycol) fumarate] hydrogels

GE Rooney, AM Knight, NN Madigan… - … Engineering Part A, 2011 - liebertpub.com
This study describes the use of oligo [(polyethylene glycol) fumarate](OPF) hydrogel
scaffolds as vehicles for sustained delivery of dibutyryl cyclic adenosine monophosphate …

[HTML][HTML] Enhancing neuroprotective effect of aminosalicylic acid-grafted chitosan electrospun fibers for spinal cord injury

D Wang, H Zhao, C Xu, S Lin, Y Guo - Materials Today Bio, 2023 - Elsevier
The hyperinflammation microenvironment after spinal cord injury (SCI) remains a great
challenge for neural regeneration. Methylprednisolone has been used to reduce the …

Reactive oxide species-scavenging lipid-polymer nanoparticles for neuroprotection after spinal cord injury

T Zhang, F Lin, W Liu, Y Liu, Z Guo, C Xiao… - Applied Materials …, 2021 - Elsevier
Suppression of secondary damage following traumatic spinal cord injury (SCI) remains a
great challenge in the clinical treatment of acute SCI. To date, the most validated treatment …

[HTML][HTML] Localized and sustained delivery of erythropoietin from PLGA microspheres promotes functional recovery and nerve regeneration in peripheral nerve injury

W Zhang, Y Gao, Y Zhou, J Liu, L Zhang… - BioMed Research …, 2015 - hindawi.com
Erythropoietin (EPO) has been demonstrated to exert neuroprotective effects on peripheral
nerve injury recovery. Though daily intraperitoneal injection of EPO during a long period of …

In Situ Cross-Linkable Hyaluronic–Ferulic Acid Conjugate Containing Bucladesine Nanoparticles Promotes Neural Regeneration after Spinal Cord Injury

F Sorouri, P Hosseini, M Sharifzadeh… - … Applied Materials & …, 2023 - ACS Publications
Dysfunctional clinical outcomes following spinal cord injury (SCI) result from glial scar
formation, leading to the inhibition of new axon growth and impaired regeneration …