As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA
modification processes have been reported, and they are widely present in every organism …

Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

Empowered by recent advances of sequencing techniques, transcriptome-wide studies have
characterized over 150 different types of post-transcriptional chemical modifications of RNA …

The activity of RNA is controlled by different types of post-transcriptional modifications, such
as the addition of methyl groups and other chemical and structural changes, that have been …

Over 170 chemical modifications have been identified in protein-coding and noncoding
RNAs and shown to exhibit broad impacts on gene expression. Dysregulation of RNA …

Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …

RNA modifications can be added or removed by a variety of enzymes that catalyse the
necessary reactions, and these modifications play roles in essential molecular mechanisms …

The broad application of next-generation sequencing technologies in conjunction with
improved bioinformatics has helped to illuminate the complexity of the transcriptome, both in …

Although cancer was originally considered a disease driven only by genetic mutations, it has
now been proven that it is also an epigenetic disease driven by DNA hypermethylation …

RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …