Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia

S Enoksson, SK Caprio, F Rife… - The journal of …, 2003 - academic.oup.com
The increased risk of hypoglycemia during intensified treatment of type 1 diabetes mellitus
(T1DM) patients, who have a deficient glucagon secretory response, is largely attributed to …

Combined Hyperinsulinemia and Hyperglycemia, But Not Hyperinsulinemia Alone, Suppress Human Skeletal Muscle Lipolytic Activity in Vivo

V Qvisth, E Hagström-Toft, S Enoksson… - The Journal of …, 2004 - academic.oup.com
Effects of circulating insulin and glucose concentrations on skeletal muscle and adipose
tissue lipolytic activity were investigated in 10 type 1 diabetes patients with no endogenous …

[PDF][PDF] Stimulation of adipose tissue lipolysis following insulin-induced hypoglycaemia: evidence of increased beta-adrenoceptor-mediated lipolytic response in IDDM

J Bolinder, S Sjöberg, P Arner - Diabetologia, 1996 - researchgate.net
The adrenergic regulation of adipose tissue lipolysis in response to insulin-induced
hypoglycaemia (intravenous infusion of soluble insulin 0.10 IU-kg body weight"-h" until the …

The role of intramyocellular lipids during hypoglycemia in patients with intensively treated type 1 diabetes

E Bernroider, A Brehm, M Krssak… - The Journal of …, 2005 - academic.oup.com
Context: Endocrine defensive mechanisms provide for energy supply during hypoglycemia.
Intramyocellular lipids (IMCL) were recently shown to contribute to energy supply during …

Human Skeletal Muscle Lipolysis Is More Responsive to Epinephrine Than to Norepinephrine Stimulation in Vivo

V Qvisth, E Hagström-Toft, S Enoksson… - The Journal of …, 2006 - academic.oup.com
Context: Triglyceride (TG) deposits in skeletal muscle (SM) are an important energy
reservoir, and increased im TG content is associated with muscle insulin resistance …

Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans

M Stumvoll, S Jacob, HG Wahl, B Hauer… - The Journal of …, 2000 - academic.oup.com
In addition to sc and visceral fat deposits, muscle has been shown to contain relevant
amounts of lipids whose breakdown is subject to hormonal regulation. The aim of the …

Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates

EL Lim, KG Hollingsworth, FE Smith… - Clinical …, 2011 - portlandpress.com
Suppression of lipolysis by acipimox is known to improve insulin-stimulated glucose
disposal, and this is an important phenomenon. The mechanism has been assumed to be …

Relationship between insulin-mediated glucose disposal by muscle and adipose tissue lipolysis in healthy volunteers

D Pei, YDI Chen, CB Hollenbeck… - The Journal of …, 1995 - academic.oup.com
The present study was performed in 17 nondiabetic subjects and was initiated to determine
whether enhanced adipose tissue lipolysis, either basal or catecholamine induced …

Regulation and Counterregulation of Lipolysis in Vivo: Different Roles of Sympathetic Activation and Insulin

LCC Navegantes, M Sjostrand… - The Journal of …, 2003 - academic.oup.com
To obtain further information on the regulation of lipolysis in vivo, the effect of increasing
sympathetic nerve activity via lower body negative pressure (LBNP,− 20 mm Hg) was …

Lack of effect of hyperglycemia on lipolysis in humans

M Caruso, GD Divertie, MD Jensen… - American Journal of …, 1990 - journals.physiology.org
Controversy exists regarding whether plasma glucose concentrations are independently
involved in the regulation of adipose tissue lipolysis. In the present study, six subjects with …