P-selectin inhibition has been evaluated as a therapeutic for prevention and treatment of
venous thrombosis. In this study, a novel oral small-molecule inhibitor of P-selectin, PSI-421 …

P-selectin inhibition has been shown to decrease thrombogenesis in multiple animal
species. In this study, we show that a novel oral small-molecule inhibitor of P-selectin, PSI …

BACKGROUND: P-selectin inhibition with protein therapeutics such as antibodies or soluble
ligands given intravenously can decrease thrombosis in a mouse ligation model of venous …

Inhibition of P-selectin by antibody or selectin antagonist decreases inflammation and
thrombosis. This study evaluates the dose-response relationship using a selectin receptor …

P-selectin plays a significant and well documented role in vascular disease by mediating
leukocyte and platelet rolling and adhesion. This study characterizes the in vitro activity …

P-selectin antagonism decreases thrombosis and inflammation in animal models of venous
thrombosis (VT) prophylaxis. This study defines results using a P-selectin receptor …

Background: Interaction of P‐selectin with its glycoprotein ligand (P‐selectin glycoprotein
ligand type 1) mediates inflammatory processes that may also include vascular thrombosis …

BACKGROUND: Vein wall injury after thrombosis is multifactorial but seems dependent on
thrombus and local thrombotic and inflammatory mechanisms. We hypothesized that …

Leukocyte adhesion, transendothelial migration, and stasis are important components in the
pathogenesis of deep vein thrombosis. Anesthetized cats were treated with saline, a …

Purpose: The purpose of this study was to compare the efficacy of P-selectin inhibition with
standard anticoagulant and thrombolytic therapy in a rodent model of established deep vein …