Background One of the causes of antibiotic resistance is the reduced accumulation of
antibiotics in bacterial cells through pumping out the drugs. Silybin, a key component of the …

Background: Pseudomonas aeruginosa is an opportunistic nosocomial pathogen that using
several classes of antibiotics to treat has been led to the emergence of multiple drug …

Antibiotic resistance has become a global health problem for humankind. Improper use of
antibiotics resulted in the increasing evolved bacterial resistance to them. There are different …

Sanjin Tablets are completely natural preparation with significant efficacy in treating urinary
tract infection. To identify the bioactive compounds from Sanjin Tablets, we separated …

Abstract Multidrug-resistant (MDR) gram-negative bacteria pose significant challenges to the
public health. Various factors are involved in the development and spread of MDR strains …

Overexpression of the efflux pump is a predominant mechanism by which bacteria show
antimicrobial resistance (AMR) and leads to the global emergence of multidrug resistance …

Alkaloid-containing natural compounds have shown promise in the treatment of microbial
infections. However, practical application of many of these compounds is pending a …

The escalating prevalence of carbapenem-resistant Pseudomonas aeruginosa (CRPA)
poses a significant threat to global public health through the spread of its 'high-risk'clones …

Antibacterial and synergy potential of naturally occurring indole alkaloids (IA): 10‐methoxy
tetrahydroalstonine (1), isoreserpiline (2), 10 and 11 demethoxyreserpiline (3), reserpiline …

Bacterial efflux pumps have emerged as antibiotic resistance determinants and confers multi-
drug resistance to a broad range of antimicrobials as well as non-antibiotic substances. A …