[HTML][HTML] Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors

A Gaurav, P Bakht, M Saini, S Pandey… - …, 2023 - microbiologyresearch.org
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …

[PDF][PDF] Anticancer drugs as potential inhibitors of AcrAB-TolC of multidrug resistant Escherichia coli: an in silico molecular modeling and docking study

P GUPTA, N RAI, P GAUTAM - Anticancer Drugs, 2015 - academia.edu
ABSTRACT Objective: Overexpression of AcrAB-TolC protein complex is often associated
with the virulence of multidrug-resistant bacteria. Development of an effective efflux pump …

Screening of natural products and derivatives for the identification of RND efflux pump inhibitors

D Choudhury, A Das Talukdar, P Chetia… - … Chemistry & High …, 2016 - ingentaconnect.com
Aim and objective: Overexpression of efflux pumps belonging to the Resistance Nodulation
cell Division (RND) family is the most important intrinsic resistance mechanism of …

Advances in the study of the microbial efflux pumps and its inhibitors development

QX Long, PF Zhou, ZH Wu, HH Wang… - Yao xue xue bao= Acta …, 2008 - europepmc.org
Drug resistant bacteria is an increasingly urgent challenge to public health. Bacteria
adaptation and extensive abuse of antibiotics contribute to this dilemma. Active efflux of …

Orthosipon stamineus extract exerts inhibition of bacterial adhesion and chaperon-usher system of uropathogenic Escherichia coli—a transcriptomic study

SS Beydokhti, C Stork, U Dobrindt, A Hensel - Applied microbiology and …, 2019 - Springer
Specific recognition and bacterial adhesion to host cells by uropathogenic Escherichia coli
(UPEC) are the first steps towards infection of epithelial tissue of the human urogenital …

Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics

C Opoku-Temeng, KI Onyedibe, UK Aryal… - Journal of proteomics, 2019 - Elsevier
Halogenated 4-hydroxybenzylidene indolinones have been shown to re-sensitize methicillin-
resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis …

Preparation, characterization, and antibacterial competence of silymarin and its nano-formulation

FS Alshehri, E Kotb, M Nawaz… - Journal of …, 2022 - Taylor & Francis
Nowadays, antibiotic resistance is a serious problem, especially in countries that have
unregulated use of antibiotics. We aimed to prepare and characterize Sily-Nano from …

Phytomolecules against bacterial biofilm and efflux pump: an in silico and in vitro study

R Jhanji, V Bhati, A Singh, A Kumar - Journal of biomolecular …, 2020 - Taylor & Francis
Antibiotic resistance is a global threat whose incidences are increasing day by day
worldwide. Thus, there is a need for new chemical entities (NCEs) or exploration of existing …

[HTML][HTML] Sodium Malonate Inhibits the AcrAB-TolC Multidrug Efflux Pump of Escherichia coli and Increases Antibiotic Efficacy

A Cauilan, C Ruiz - Pathogens, 2022 - mdpi.com
There is an urgent need to find novel treatments for combating multidrug-resistant bacteria.
Multidrug efflux pumps that expel antibiotics out of cells are major contributors to this …

In silico genetic correlations of multidrug efflux pump gene expression in Staphylococcus aureus

C Kosmidis, CE DeMarco, E Frempong-Manso… - International journal of …, 2010 - Elsevier
Regulatory mechanisms for chromosomal genes encoding multidrug resistance (MDR)
efflux pumps (EPs) in Staphylococcus aureus are poorly defined. Microbiological …