Antimicrobial resistance poses a significant challenge to public health, especially in
developing countries, due to a substantial rise in bacterial resistance. This situation has …

Carbapenem antibiotics are widely used for their broad antibacterial effects, but the
emergence of carbapenem-resistant Enterobacterales has recently become a global …

Multidrug resistance pathogens causing infections and illness remain largely untreated
clinically. Efflux pumps are one of the primary processes through which bacteria develop …

Therapeutics that target the virulence of pathogens rather than their viability offer a
promising alternative for treating infectious diseases and circumventing antibiotic resistance …

Urinary tract infections (UTIs) are one of the commonest bacterial infections worldwide. The
most common etiological agent is uropathogenic Escherichia coli. The occurrence of high …

Multidrug efflux pump is one of the reasons behind the antimicrobial inactivity related to
infection caused by Gram-negative pathogens. The inner membrane resistance–nodulation …

The occurrence of bacterial resistance has been increasing, compromising the treatment of
various infections. The high virulence of Staphylococcus aureus allows for the maintenance …

Pseudomonas aeruginosa can cause a variety of healthcare-associated infections by its
arsenal of virulence factors. Virulence factor production is largely controlled by the cell-to …

Urinary tract infections (UTIs) are becoming more common, requiring extensive protection
from antimicrobials. The global expansion of multi-drug resistance uropathogens in the past …

ABSTRACT Objective: Multidrug resistant Pseudomonas aeruginosa possess multiple ways
of resistance with the expression of efflux pump proteins as one of the major mechanisms …