Most of the leading causes of death, such as cardiovascular diseases, cancer, dementia,
neurodegenerative diseases, and many more, are associated with sterile inflammation …

Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …

Background: Macrophages (Mφs) participate in wound healing by coordinating inflammatory
and angiogenic processes. Mφs respond to environmental cues by adopting either …

Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

Neutralizing injurious stimuli, proinflammatory mediator catabolism, and polymorphonuclear
leukocyte (PMN) clearance are determinants of inflammatory resolution. To this, we recently …

Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …

Damage-associated molecular patterns (DAMPs) are endogenous molecules that are
released from host cells as a result of cell death or damage. The release of DAMPs in …

Associated with the development of hospital-acquired infections, major traumatic injury
results in an immediate and persistent state of systemic immunosuppression, yet the …

Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …

Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …